Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | DHFR | P00374 | 3/20 | 0.41 |
| ▸ | AGXT | P21549 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2599592 | 0.87 | ADRA2C (0.49) | MAPTNPC1DHFRAGXTALDH1A1 | |
| SCHEMBL2597597 | 0.87 | DHFR (0.45) | MAPTDHFRAGXTF10ALDH1A1 | |
| SCHEMBL3653339 | 0.85 | CHRNA3 (0.42) | MAPTNPC1DHFRAGXTF10 | |
| SCHEMBL3650213 | 0.82 | F10 (0.41) | MAPTNPC1DHFRAGXTF10 | |
| SCHEMBL11510734 | 0.79 | SLC6A2 (0.52) | MAPTAGXTALDH1A1KDM4EMEN1 | |
| SCHEMBL30228382 | 0.77 | SLC6A2 (0.51) | MAPTAGXTF10ALDH1A1KDM4E | |
| SCHEMBL3594431 | 0.74 | APP (0.61) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL3656991 | 0.73 | ADRA2C (0.47) | MAPTNPC1AGXTHTR3EHTR3B | |
| SCHEMBL2599593 | 0.73 | AKR1C3 (0.45) | MAPTDHFRAGXTF10MEN1 | |
| SCHEMBL2399483 | 0.73 | AGXT (0.44) | MAPTNPC1AGXTF10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571856-A1 | COMPOUNDS | BTG International Limited (GB) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144577-A1 | COMPOUNDS | SENEXIS LIMITED (GB) | 2011-11-24 | — | — | WO | disclosed |