Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | AGXT | P21549 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 2/20 | 0.44 |
| ▸ | CTSC | P53634 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2597646 | 0.87 | MAPT (0.42) | NPC1MAPTAGXTHTR3AALDH1A1 | |
| SCHEMBL3656991 | 0.86 | ADRA2C (0.47) | ADRA2CNPC1MAPTAGXTEGFR | |
| SCHEMBL2597597 | 0.83 | DHFR (0.45) | MAPTAGXTALDH1A1DHFR | |
| SCHEMBL1040397 | 0.77 | EGFR (0.56) | ADRA2CNPC1MAPTEGFRCTSC | |
| SCHEMBL28514042 | 0.75 | SMN1; SMN2 (0.54) | ADRA2CMAPTHTR3AALDH1A1MEN1 | |
| SCHEMBL28538439 | 0.75 | HRH4 (0.45) | HTR3AALDH1A1DRD2HRH4 | |
| SCHEMBL18938300 | 0.74 | ADRA2C (0.59) | ADRA2CNPC1MAPTAGXTHTR3A | |
| SCHEMBL29814948 | 0.74 | ADRA2C (0.59) | ADRA2CNPC1MAPTAGXTHTR3A | |
| SCHEMBL1372927 | 0.74 | KCNH2 (0.69) | ADRA2CNPC1MAPTAGXTHTR3A | |
| SCHEMBL3653339 | 0.73 | CHRNA3 (0.42) | NPC1MAPTAGXTALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571872-B1 | COMPOUNDS | TREHERNE JOHNATHAN MARK (GB) | 2014-12-31 | — | — | EP | disclosed |
| EP-2571872-B1 | COMPOUNDS | TREHERNE JOHNATHAN MARK (GB) | 2014-12-31 | — | — | EP | disclosed |
| EP-2571872-A1 | COMPOUNDS | BTG International Limited (GB) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144578-A1 | COMPOUNDS | SENEXIS LIMITED (GB) | 2011-11-24 | — | — | WO | disclosed |