Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | EDNRA | P25101 | 2/20 | 0.46 |
| ▸ | EDNRB | P24530 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.42 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21253062 | 0.84 | MAPT (0.49) | HSD17B10EDNRAEDNRBCYP1A2HTR2A | |
| SCHEMBL3751967 | 0.83 | HSD17B10 (0.58) | HSD17B10EDNRAEDNRBCYP1A2HTR2A | |
| SCHEMBL13135997 | 0.83 | HSD17B10 (0.50) | HSD17B10CYP1A2HTR2AHTR2CHTR2B | |
| SCHEMBL125094 | 0.81 | MAPT (0.44) | HSD17B10EDNRAEDNRBCYP1A2HTR2B | |
| SCHEMBL8585951 | 0.81 | MAPT (0.44) | HSD17B10EDNRAEDNRBCYP1A2HTR2B | |
| SCHEMBL11612863 | 0.80 | HSD17B10 (0.55) | HSD17B10EDNRAEDNRBCYP1A2HTR2A | |
| SCHEMBL22333014 | 0.79 | HSD17B10 (0.50) | HSD17B10EDNRAEDNRBCYP1A2HTR2A | |
| SCHEMBL19551118 | 0.79 | HSD17B10 (0.50) | HSD17B10EDNRAEDNRBCYP1A2HTR2A | |
| SCHEMBL19551053 | 0.79 | HSD17B10 (0.50) | HSD17B10EDNRAEDNRBCYP1A2HTR2A | |
| SCHEMBL14398778 | 0.77 | HSD17B10 (0.51) | HSD17B10EDNRAEDNRBCYP1A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452466-B1 | HETEROCYCLIC TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-08-12 | — | — | EP | disclosed |
| US-10150760-B2 | Compounds for use in preparing heterocyclic triazole agonists of the APJ receptor | AMGEN INC. (US) | 2018-12-11 | — | — | US | disclosed |
| US-20180222895-A1 | COMPOUNDS FOR USE IN PREPARING HETEROCYCLIC TRIAZOLE AGONISTS OF THE APJ RECEPTOR | AMGEN INC. | 2018-08-09 | — | — | US | disclosed |
| US-9988369-B2 | Heterocyclic triazole compounds as agonists of the APJ receptor | AMGEN INC. (US) | 2018-06-05 | — | — | US | disclosed |
| US-20170320860-A1 | HETEROCYCLIC TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. | 2017-11-09 | — | — | US | disclosed |
| EP-2571860-A1 | 2-PHENYL BENZOYLAMIDES | Pfizer Inc (US) | 2013-03-27 | — | — | EP | disclosed |
| US-20130072519-A1 | 2-PHENYL BENZOYLAMIDES | CONN EDWARD LEE (US) | 2013-03-21 | — | — | US | disclosed |
| WO-2011145022-A1 | 2-PHENYL BENZOYLAMIDES | PFIZER INC. (US) | 2011-11-24 | — | — | WO | disclosed |
| US-7795267-B2 | Bicyclic piperazine compound having TGR23 antagonistic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-14 | — | — | US | disclosed |
| US-20070072865-A1 | Bicyclic piperazine compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-03-29 | — | — | US | disclosed |
| EP-0261803-A1 | Improved process for [1H]-isoindolin-1-one-3-carboxylic acid | PFIZER INC. (US) | 1988-03-30 | — | — | EP | disclosed |
| US-4730056-A | Process for (1H)-isoindolin-1-one-3-carboxylic acid | PFIZER INC. (US) | 1988-03-08 | — | — | US | disclosed |
| US-4730056-A | Process for (1H)-isoindolin-1-one-3-carboxylic acid | PFIZER INC. (US) | 1988-03-08 | — | — | US | disclosed |
| US-4730056-A | Process for (1H)-isoindolin-1-one-3-carboxylic acid | PFIZER INC. (US) | 1988-03-08 | — | — | US | disclosed |
| EP-0093805-B1 | OCTAHYDRO-2-(OMEGA-MERCAPTOALKANOYL)3-OXO-1H-ISOINDOLE-1-CARBOXYLIC ACIDS AND ESTERS | WARNER-LAMBERT COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |
| US-4503043-A | HYPOTENSIVES | WARNER-LAMBERT COMPANY (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0058567-B1 | SUBSTITUTED ACYL DERIVATIVES OF OCTAHYDRO-1H-ISOINDOLE-1-CARBOXYLIC ACIDS AND ESTERS | WARNER-LAMBERT COMPANY (US) | 1984-07-25 | — | — | EP | disclosed |
| EP-0093805-A1 | Octahydro-2-(omega-mercaptoalkanoyl)3-oxo-1H-isoindole-1-carboxylic acids and esters | WARNER-LAMBERT COMPANY (US) | 1983-11-16 | — | — | EP | disclosed |
| EP-0058567-A1 | Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids and esters | WARNER-LAMBERT COMPANY (US) | 1982-08-25 | — | — | EP | disclosed |
| US-4324667-A | Process for purification of waste waters from aromatic amines | KONSTANTINOV IGOR I | 1982-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222895-A1 | COMPOUNDS FOR USE IN PREPARING HETEROCYCLIC TRIAZOLE AGONISTS OF THE APJ RECEPTOR | TBXA2R, APLNR, GPR27 | HSD17B10 2969/4885EDNRA 211/4885EDNRB 228/4885 |
| US-20130072519-A1 | 2-PHENYL BENZOYLAMIDES | APOB, MTTP, HADHB | HSD17B10 191/4885EDNRA 3617/4885EDNRB 2280/4885 |
| US-20070072865-A1 | Bicyclic piperazine compound and use thereof | GPR3, FFAR3, LPAR3 | HSD17B10 514/4885EDNRA 481/4885EDNRB 445/4885 |
| US-10150760-B2 | Compounds for use in preparing heterocyclic triazole agonists of the APJ receptor | TBXA2R, APLNR, GPR27 | HSD17B10 2969/4885EDNRA 211/4885EDNRB 228/4885 |
| US-20170320860-A1 | HETEROCYCLIC TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | TBXA2R, APLNR, AGTR1 | HSD17B10 1912/4885EDNRA 65/4885EDNRB 99/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.