Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 1.00 |
| ▸ | RAB9A | P51151 | 11/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 11/20 | 1.00 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.82 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.70 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037903 | 0.90 | L3MBTL1 (1.00) | NPC1RAB9AALOX12NCOA3L3MBTL1 | |
| SCHEMBL2598271 | 0.87 | ALOX12 (1.00) | NPC1RAB9AALOX12NCOA3L3MBTL1 | |
| SCHEMBL2153766 | 0.84 | NPC1 (0.86) | NPC1RAB9AALOX12NCOA3L3MBTL1 | |
| SCHEMBL1811300 | 0.82 | NPC1 (1.00) | NPC1RAB9AALOX12NCOA3L3MBTL1 | |
| SCHEMBL27790138 | 0.82 | NPC1 (0.80) | NPC1RAB9AALOX12NCOA3L3MBTL1 | |
| SCHEMBL4037950 | 0.81 | NPC1 (0.85) | NPC1RAB9AALOX12NCOA3L3MBTL1 | |
| SCHEMBL27790128 | 0.81 | NPC1 (0.86) | NPC1RAB9AALOX12NCOA3L3MBTL1 | |
| SCHEMBL4035597 | 0.81 | NPC1 (0.86) | NPC1RAB9AALOX12NCOA3L3MBTL1 | |
| SCHEMBL2598267 | 0.81 | NPC1 (1.00) | NPC1RAB9AALOX12NCOA3L3MBTL1 | |
| SCHEMBL4045007 | 0.81 | NPC1 (0.78) | NPC1RAB9AALOX12NCOA3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130096159-A1 | INHIBITORS OF HUMAN 12-LIPOXYGENASE | The United States of America, as represented the Secretary Department of Health & Human Service (US) | 2013-04-18 | — | — | US | claimed |
| US-20130096159-A1 | INHIBITORS OF HUMAN 12-LIPOXYGENASE | The United States of America, as represented the Secretary Department of Health & Human Service (US) | 2013-04-18 | — | — | US | disclosed |
| EP-2571853-A1 | INHIBITORS OF HUMAN 12-LIPOXYGENASE | The U.S.A. as represented by the Secretary, Department of Health and Human Services (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146618-A1 | INHIBITORS OF HUMAN 12-LIPOXYGENASE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096159-A1 | INHIBITORS OF HUMAN 12-LIPOXYGENASE | ALOX12, ALOX15B, ALOX15 | NPC1 2330/4885RAB9A 2761/4885ALOX12 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.