Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25985150 | 0.79 | SMN1; SMN2 (0.49) | KDM4EALDH1A1LMNAGAAMAPT | |
| SCHEMBL25985081 | 0.77 | AXL (0.43) | KDM4EALDH1A1PTPN11POLBCYP3A4 | |
| SCHEMBL25981002 | 0.75 | MAPT (0.47) | KDM4EALDH1A1L3MBTL1XDHNOTUM | |
| SCHEMBL25984535 | 0.73 | L3MBTL1 (0.44) | KDM4EALDH1A1POLBL3MBTL1GAA | |
| SCHEMBL583270 | 0.72 | KDM4E (0.64) | KDM4EALDH1A1PTPN11POLBLMNA | |
| SCHEMBL20488880 | 0.71 | KDM4E (0.55) | KDM4EALDH1A1PTPN11POLBLMNA | |
| SCHEMBL22655542 | 0.70 | KDM4E (0.55) | KDM4EALDH1A1PTPN11POLBCYP3A4 | |
| SCHEMBL583987 | 0.70 | ALDH1A1 (0.79) | KDM4EALDH1A1POLBLMNAL3MBTL1 | |
| SCHEMBL17184635 | 0.68 | LMNA (0.50) | KDM4EALDH1A1POLBCYP3A4LMNA | |
| SCHEMBL17894021 | 0.68 | LMNA (0.58) | KDM4EALDH1A1PTPN11POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250145599-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | MRJA THERAPEUTICS, INC. | 2025-05-08 | — | — | US | disclosed |
| CN-118974019-A | Certain chemical entities, compositions and methods | 瑞图恩制药公司 | 2024-11-15 | — | — | CN | disclosed |
| WO-2023150663-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | RETUNE PHARMA INC. (US) | 2023-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250145599-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | IGF1R, IGFBP1, IGFBP2 | KDM4E 3842/4885ALDH1A1 826/4885PTPN11 1417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.