Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 6/20 | 0.43 |
| ▸ | LPAR3 | Q9UBY5 | 4/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.43 |
| ▸ | LPAR6 | P43657 | 1/20 | 0.43 |
| ▸ | LPAR4 | Q99677 | 1/20 | 0.43 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.43 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 7/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | GGPS1 | O95749 | 3/20 | 0.41 |
| ▸ | DGKA | P23743 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598936 | 0.94 | ENPP2 (0.40) | ENPP2LPAR3LPAR1LPAR6LPAR4 | |
| SCHEMBL2598916 | 0.79 | FDPS (0.46) | FDPSPDE3AGGPS1 | |
| SCHEMBL9500079 | 0.78 | ENPP2 (0.41) | ENPP2LPAR3LPAR1LPAR6LPAR4 | |
| SCHEMBL5995956 | 0.78 | FDPS (0.37) | FDPSPDE3ACYP1A2 | |
| SCHEMBL5615418 | 0.75 | DGKA (0.53) | ENPP2LPAR3LPAR1LPAR6LPAR4 | |
| SCHEMBL2455044 | 0.74 | FDPS (0.51) | FDPSPDE3AGGPS1 | |
| SCHEMBL2453742 | 0.74 | FDPS (0.41) | FDPSPDE3AGGPS1CYP1A2 | |
| SCHEMBL2458967 | 0.73 | FDPS (0.42) | FDPSPDE3A | |
| SCHEMBL7862033 | 0.73 | FDPS (0.50) | FDPSPDE3AGGPS1 | |
| SCHEMBL2455650 | 0.73 | FDPS (0.42) | FDPSPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416689-B1 | Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors | MERCK & CO INC (US) | 1995-11-29 | — | — | EP | claimed |
| US-5227506-A | Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors | MERCK & CO., INC. (US) | 1993-07-13 | — | — | US | claimed |
| EP-0416689-A2 | Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors | MERCK & CO. INC. (US) | 1991-03-13 | — | — | EP | claimed |
| WO-2011146819-A2 | METHODS AND COMPOSITIONS FOR TREATMENT NF-κB-MEDIATED AND α7 INTEGRIN-SUPPRESSED DISEASES | DMD THERAPIES, LLC (US) | 2011-11-24 | — | — | WO | disclosed |
| EP-0416689-B1 | Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors | MERCK & CO INC (US) | 1995-11-29 | — | — | EP | disclosed |
| US-5227506-A | Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors | MERCK & CO., INC. (US) | 1993-07-13 | — | — | US | disclosed |
| EP-0416689-A2 | Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors | MERCK & CO. INC. (US) | 1991-03-13 | — | — | EP | disclosed |