Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 6/20 | 0.41 |
| ▸ | LPAR3 | Q9UBY5 | 4/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.41 |
| ▸ | LPAR6 | P43657 | 1/20 | 0.41 |
| ▸ | LPAR4 | Q99677 | 1/20 | 0.41 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.41 |
| ▸ | P2RY10 | O00398 | 9/20 | 0.40 |
| ▸ | GPR174 | Q9BXC1 | 5/20 | 0.40 |
| ▸ | GPR34 | Q9UPC5 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598936 | 0.84 | ENPP2 (0.40) | ENPP2LPAR3LPAR1LPAR6LPAR4 | |
| SCHEMBL2599116 | 0.78 | ENPP2 (0.43) | ENPP2LPAR3LPAR1LPAR6LPAR4 | |
| SCHEMBL5615800 | 0.70 | DGKA (0.55) | ENPP2LPAR3LPAR1LPAR6LPAR4 | |
| SCHEMBL5615418 | 0.69 | DGKA (0.53) | ENPP2LPAR3LPAR1LPAR6LPAR4 | |
| SCHEMBL2458691 | 0.69 | FDPS (0.53) | — | |
| SCHEMBL2453742 | 0.68 | FDPS (0.41) | — | |
| SCHEMBL25685154 | 0.68 | ENPP2 (0.67) | ENPP2LPAR3LPAR1LPAR6LPAR4 | |
| SCHEMBL2597966 | 0.67 | ENPP2 (0.41) | ENPP2LPAR3LPAR1LPAR6LPAR4 | |
| SCHEMBL5615415 | 0.66 | DGKA (0.53) | ENPP2LPAR3LPAR1LPAR6LPAR4 | |
| SCHEMBL5615799 | 0.66 | DGKA (0.57) | ENPP2LPAR3LPAR1LPAR6LPAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5227506-A | Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors | MERCK & CO., INC. (US) | 1993-07-13 | — | — | US | claimed |
| US-5227506-A | Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors | MERCK & CO., INC. (US) | 1993-07-13 | — | — | US | disclosed |