SCHEMBL2599669

SCHEMBL2599669

C1=CC(c2ccccc2)(c2ccc(N3CCCC3)cc2)Oc2cc(N3CCOCC3)c3ccccc3c21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.39
ALDH1A1 P00352 5/20 0.39
NPSR1 Q6W5P4 3/20 0.39
TSHR P16473 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
HPGD P15428 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
GAA P10253 2/20 0.39
POLB P06746 1/20 0.39
HSD17B10 Q99714 1/20 0.39
MAPT P10636 5/20 0.38
LMNA P02545 3/20 0.38
CYP3A4 P08684 1/20 0.38
THRB P10828 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
BLM P54132 1/20 0.38
NCF1 P14598 2/20 0.37
PKM P14618 1/20 0.36
PRKDC P78527 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2412684 0.99 ALDH1A1 (0.41) KDM4EALDH1A1NPSR1TSHRSMN1; SMN2
SCHEMBL29501170 0.99 ALDH1A1 (0.41) KDM4EALDH1A1NPSR1TSHRSMN1; SMN2
SCHEMBL8506443 0.98 NPSR1 (0.40) KDM4EALDH1A1NPSR1TSHRSMN1; SMN2
SCHEMBL29375632 0.97 KDM4E (0.40) KDM4EALDH1A1NPSR1TSHRSMN1; SMN2
SCHEMBL1408640 0.97 KDM4E (0.40) KDM4EALDH1A1NPSR1TSHRSMN1; SMN2
SCHEMBL4784200 0.92 NCF1 (0.42) KDM4EALDH1A1NPSR1TSHRSMN1; SMN2
SCHEMBL12206758 0.91 ALDH1A1 (0.37) KDM4EALDH1A1NPSR1TSHRSMN1; SMN2
SCHEMBL12205327 0.91 ALDH1A1 (0.37) KDM4EALDH1A1NPSR1TSHRSMN1; SMN2
SCHEMBL21338487 0.91 ALDH1A1 (0.37) KDM4EALDH1A1NPSR1TSHRSMN1; SMN2
SCHEMBL6169045 0.90 ALDH1A1 (0.38) KDM4EALDH1A1NPSR1TSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0973761-B1 RED COLOURING HYPERCHROMIC 3H-NAPHTHO 2,1-b ]PYRANS JAMES ROBINSON LTD (GB) 2002-07-03 EP claimed
US-6294112-B1 Red coloring hyperchromic 3H-naphtho[2,1-B]pyrans JAMES ROBINSON LIMITED (GB) 2001-09-25 US claimed
WO-1999031081-A1 PH SENSITIVE PHOTOCHROMIC DYES JAMES ROBINSON LIMITED (GB) 1999-06-24 WO claimed
EP-2571944-A1 METHOD FOR PRODUCING A COATING COMPOSITION HAVING REVERSIBLE COLOR SHADE CHANGE PROPERTIES, FOR RENDERING SUBSTRATES UV-ABSORBING Graf, Thorsten (DE) 2013-03-27 EP disclosed
WO-2011144354-A1 METHOD FOR PRODUCING A COATING COMPOSITION HAVING REVERSIBLE COLOR SHADE CHANGE PROPERTIES, FOR RENDERING SUBSTRATES UV-ABSORBING GRAF, THORSTEN (DE) 2011-11-24 WO disclosed
EP-1964189-B1 COLOR TUNABLE LIGHT-EMITTING DEVICES AND METHOD OF MAKING THE SAME GEN ELECTRIC (US) 2010-08-18 EP disclosed
EP-1964189-A1 COLOR TUNABLE LIGHT-EMITTING DEVICES AND METHOD OF MAKING THE SAME General Electric Company (US) 2008-09-03 EP disclosed
WO-2008043853-A2 PHOTOCHROMIC FILM OPCO GMBH (DE) 2008-04-17 WO disclosed
US-7335702-B2 Photochromic plastic object RODENSTOCK GMBH (DE) 2008-02-26 US disclosed
WO-2007134680-A1 PHOTOCHROMIC PLASTIC OBJECT WITH INCREASED CONTRAST, AS WELL AS A REDUCTION OF SCATTERING EFFECTS AND GLARES RODENSTOCK GMBH (DE) 2007-11-29 WO disclosed
EP-1194798-B1 PHOTOCHROMIC PLASTIC OBJECT WITH PERMANENTLY INCREASED CONTRAST RODENSTOCK GMBH (DE) 2007-06-27 EP disclosed
WO-2002060984-A1 PHOTOCHROMIC PLASTIC OBJECT RODENSTOCK GMBH (DE) 2002-08-08 WO disclosed
EP-0973761-B1 RED COLOURING HYPERCHROMIC 3H-NAPHTHO 2,1-b ]PYRANS JAMES ROBINSON LTD (GB) 2002-07-03 EP disclosed
US-6373615-B1 Neutral-colored gray photochromic plastic object OPTISCHE WERKE G. RODENSTOCK (DE) 2002-04-16 US disclosed
EP-1194798-A1 PHOTOCHROMIC PLASTIC OBJECT WITH PERMANENTLY INCREASED CONTRAST Optische Werke G. Rodenstock (DE) 2002-04-10 EP disclosed
WO-2001092926-A1 PHOTOCHROMIC PLASTIC OBJECT WITH PERMANENTLY INCREASED CONTRAST OPTISCHE WERKE G. RODENSTOCK (DE) 2001-12-06 WO disclosed
US-6306316-B1 Photochromic plastic object OPTISCHE WERKE G. RODENSTOCK (DE) 2001-10-23 US disclosed
US-6294112-B1 Red coloring hyperchromic 3H-naphtho[2,1-B]pyrans JAMES ROBINSON LIMITED (GB) 2001-09-25 US disclosed
EP-1099743-A1 Photochromic plastic article Optische Werke G. Rodenstock (DE) 2001-05-16 EP disclosed
WO-1999031081-A1 PH SENSITIVE PHOTOCHROMIC DYES JAMES ROBINSON LIMITED (GB) 1999-06-24 WO disclosed