SCHEMBL4784200

SCHEMBL4784200

C1=CC(c2ccccc2)(c2ccccc2)Oc2cc(N3CCOCC3)c3ccccc3c21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NCF1 P14598 2/20 0.42
KDM4E B2RXH2 3/20 0.42
NPSR1 Q6W5P4 2/20 0.42
LMNA P02545 2/20 0.42
CYP3A4 P08684 1/20 0.42
MAPT P10636 1/20 0.42
THRB P10828 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
BLM P54132 1/20 0.42
ALDH1A1 P00352 3/20 0.41
HSD17B10 Q99714 2/20 0.41
POLB P06746 1/20 0.41
GAA P10253 1/20 0.41
HPGD P15428 1/20 0.41
TSHR P16473 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
PRKDC P78527 7/20 0.40
METAP1 P53582 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1408640 0.95 KDM4E (0.40) NCF1KDM4ENPSR1LMNACYP3A4
SCHEMBL29375632 0.95 KDM4E (0.40) NCF1KDM4ENPSR1LMNACYP3A4
SCHEMBL12618090 0.93 NCF1 (0.43) NCF1KDM4ENPSR1LMNACYP3A4
SCHEMBL2599669 0.92 KDM4E (0.39) NCF1KDM4ENPSR1LMNACYP3A4
SCHEMBL29501170 0.92 ALDH1A1 (0.41) NCF1KDM4ENPSR1LMNACYP3A4
SCHEMBL2412684 0.92 ALDH1A1 (0.41) NCF1KDM4ENPSR1LMNACYP3A4
SCHEMBL2417015 0.91 PRKDC (0.40) NCF1KDM4ENPSR1LMNACYP3A4
SCHEMBL2599684 0.91 BCHE (0.44) NCF1KDM4ENPSR1LMNACYP3A4
SCHEMBL8506443 0.90 NPSR1 (0.40) NCF1KDM4ENPSR1LMNACYP3A4
SCHEMBL2456236 0.88 PRKDC (0.41) NCF1KDM4ENPSR1LMNACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7320826-B2 comprises 3-(4-methoxyphenyl)-3-phenyl-6,7,10,11-tetramethoxy-13-ethyl-13-hydroxy-13H-3H-indeno[2,'3,'3,4]naphtho[1,2-b]pyran; for activation via actinic radiation; improved optical density response; ophthalmic lens PPG INDUSTRIES OHIO, INC. (US) 2008-01-22 US claimed
US-20040191520-A1 Photochromic articles with reduced temperature dependency and methods for preparation TRANSITIONS OPTICAL LIMITED (IE) 2004-09-30 US claimed
WO-2008043853-A2 PHOTOCHROMIC FILM OPCO GMBH (DE) 2008-04-17 WO disclosed
US-7335702-B2 Photochromic plastic object RODENSTOCK GMBH (DE) 2008-02-26 US disclosed
US-7320826-B2 comprises 3-(4-methoxyphenyl)-3-phenyl-6,7,10,11-tetramethoxy-13-ethyl-13-hydroxy-13H-3H-indeno[2,'3,'3,4]naphtho[1,2-b]pyran; for activation via actinic radiation; improved optical density response; ophthalmic lens PPG INDUSTRIES OHIO, INC. (US) 2008-01-22 US disclosed
WO-2007134680-A1 PHOTOCHROMIC PLASTIC OBJECT WITH INCREASED CONTRAST, AS WELL AS A REDUCTION OF SCATTERING EFFECTS AND GLARES RODENSTOCK GMBH (DE) 2007-11-29 WO disclosed
EP-1194798-B1 PHOTOCHROMIC PLASTIC OBJECT WITH PERMANENTLY INCREASED CONTRAST RODENSTOCK GMBH (DE) 2007-06-27 EP disclosed
EP-1362077-B1 PHOTOCHROMIC PLASTIC OBJECT RODENSTOCK GMBH (DE) 2006-07-12 EP disclosed
US-6853471-B2 Photochromic synthetic resin object with permanently increased contrast RODENSTOCK GMBH (DE) 2005-02-08 US disclosed
EP-1099743-B1 Photochromic plastic article RODENSTOCK GMBH (DE) 2004-11-10 EP disclosed
WO-2004085568-A2 PHOTOCHROMIC ARTICLES WITH REDUCED TEMPERATURE DEPENDENCY AND METHODS FOR PREPARATION TRANSITIONS OPTICAL, INC. (US) 2004-10-07 WO disclosed
US-20040138382-A1 Photochromic plastic object RODENSTOCK GMBH (DE) 2004-07-15 US disclosed
EP-1362077-A1 PHOTOCHROMIC PLASTIC OBJECT Rodenstock GmbH (DE) 2003-11-19 EP disclosed
US-20020118431-A1 Photochromic synthetic resin object with permanently increased contrast SECOND OPTICAL HOLDING GMBH (DE) 2002-08-29 US disclosed
WO-2002060984-A1 PHOTOCHROMIC PLASTIC OBJECT RODENSTOCK GMBH (DE) 2002-08-08 WO disclosed
US-6373615-B1 Neutral-colored gray photochromic plastic object OPTISCHE WERKE G. RODENSTOCK (DE) 2002-04-16 US disclosed
EP-1194798-A1 PHOTOCHROMIC PLASTIC OBJECT WITH PERMANENTLY INCREASED CONTRAST Optische Werke G. Rodenstock (DE) 2002-04-10 EP disclosed
WO-2001092926-A1 PHOTOCHROMIC PLASTIC OBJECT WITH PERMANENTLY INCREASED CONTRAST OPTISCHE WERKE G. RODENSTOCK (DE) 2001-12-06 WO disclosed
EP-1099743-A1 Photochromic plastic article Optische Werke G. Rodenstock (DE) 2001-05-16 EP disclosed
WO-1999031081-A1 PH SENSITIVE PHOTOCHROMIC DYES JAMES ROBINSON LIMITED (GB) 1999-06-24 WO disclosed