Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | EBP | Q15125 | 2/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7999028 | 0.80 | L3MBTL1 (0.51) | SIGMAR1ALDH1A1L3MBTL1DRD2SLC6A4 | |
| SCHEMBL19043072 | 0.77 | ALDH1A1 (0.55) | SIGMAR1ALDH1A1L3MBTL1DRD2SLC6A4 | |
| SCHEMBL24045414 | 0.72 | LTA4H (0.57) | SIGMAR1ALDH1A1L3MBTL1DRD2SLC6A4 | |
| SCHEMBL22813479 | 0.72 | SIGMAR1 (0.50) | SIGMAR1DRD2SLC6A4SLC6A3KDM4E | |
| SCHEMBL16695075 | 0.72 | SIGMAR1 (0.52) | SIGMAR1DRD2SLC6A4SLC6A3HRH3 | |
| SCHEMBL7923062 | 0.72 | SIGMAR1 (0.72) | SIGMAR1EBPTMEM97 | |
| SCHEMBL19904406 | 0.71 | HRH3 (0.48) | SIGMAR1ALDH1A1L3MBTL1DRD2SLC6A4 | |
| SCHEMBL7922224 | 0.71 | SIGMAR1 (0.56) | SIGMAR1DRD2SLC6A4SLC6A3EBP | |
| SCHEMBL16595241 | 0.71 | SIGMAR1 (0.53) | SIGMAR1DRD2SLC6A4SLC6A3HRH3 | |
| SCHEMBL19043653 | 0.70 | SIGMAR1 (0.55) | SIGMAR1HRH3EBPTMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4048397-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THERAPEUTIC APPLICATIONS | UNIV MICHIGAN REGENTS (US) | 2023-08-16 | — | — | EP | disclosed |