Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 10/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 8/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.32 |
| ▸ | GABRE | P78334 | 1/20 | 0.32 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.32 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13315163 | 0.82 | NR3C1 (0.48) | NR3C1PGRNR3C2FFAR1FFAR4 | |
| SCHEMBL15491228 | 0.79 | FFAR1 (0.38) | PYCR1FFAR1FFAR4GABRA1GABRA5 | |
| SCHEMBL26016357 | 0.79 | PYCR1 (0.35) | NR3C1PGRNR3C2PYCR1GABRP | |
| SCHEMBL1164992 | 0.76 | FFAR1 (0.38) | PYCR1FFAR1FFAR4MAP2K2MAP2K1 | |
| SCHEMBL24837945 | 0.76 | LOXL2 (0.38) | PYCR1FFAR1FFAR4MAP2K2MAP2K1 | |
| SCHEMBL11229826 | 0.75 | GABRA1 (0.33) | PYCR1FFAR1FFAR4GABRA1GABRB2 | |
| SCHEMBL16286817 | 0.75 | PARP1 (0.36) | PYCR1FFAR1MAP2K2MAP2K1 | |
| SCHEMBL1704764 | 0.75 | IDO1 (0.48) | NR3C1PGRNR3C2 | |
| SCHEMBL17726213 | 0.73 | ADRA2B (0.45) | — | |
| SCHEMBL855374 | 0.73 | TAAR1 (0.35) | FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11731943-B2 | Therapeutic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2023-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11731943-B2 | Therapeutic compounds, compositions and methods of use thereof | JAK2, JAK1, JAK3 | NR3C1 898/4885PGR 1300/4885NR3C2 469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.