SCHEMBL26023926

SCHEMBL26023926

CC(C)(C)c1ccc(-c2ccc(F)cc2)nc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.49
RXFP1 Q9HBX9 1/20 0.49
PTPN1 P18031 1/20 0.46
PTPN6 P29350 1/20 0.46
PTPN11 Q06124 1/20 0.46
BRS3 P32247 3/20 0.45
KCNH2 Q12809 2/20 0.45
AURKA O14965 1/20 0.43
ABL1 P00519 1/20 0.43
NTRK1 P04629 1/20 0.43
LCK P06239 1/20 0.43
CSF1R P07333 1/20 0.43
RET P07949 1/20 0.43
MET P08581 1/20 0.43
PDGFRB P09619 1/20 0.43
PIM1 P11309 1/20 0.43
PDGFRA P16234 1/20 0.43
FLT3 P36888 1/20 0.43
MAPK8 P45983 1/20 0.43
CDK8 P49336 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12173603 0.88 KIF11 (0.48) NPC1ABL1KIF11KDM1AMAOB
SCHEMBL14062459 0.86 KIF11 (0.52) NPC1ABL1KIF11KDM1AMAOB
SCHEMBL26023954 0.85 KDM1A (0.53) KIF11CYP11B1CYP11B2ALOX5APKDM1A
SCHEMBL11976427 0.84 NPC1 (0.46) NPC1RXFP1PTPN1PTPN6PTPN11
SCHEMBL22079741 0.83 TSHR (0.52) NPC1AURKAABL1NTRK1LCK
SCHEMBL556994 0.83 KIF11 (0.56) NPC1RXFP1PTPN1PTPN6PTPN11
SCHEMBL11976441 0.82 NPC1 (0.45) NPC1RXFP1PTPN1PTPN6PTPN11
SCHEMBL14848446 0.82 JAK2 (0.42) NPC1RXFP1BRS3KCNH2RET
SCHEMBL12622265 0.81 NPC1 (0.50) NPC1BRS3KCNH2ABL1KIF11
SCHEMBL25557996 0.81 TSHR (0.50) NPC1AURKAABL1NTRK1LCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230371358-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-11-16 US disclosed
US-20230365606-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-11-16 US disclosed
US-20230357296-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-11-09 US disclosed
US-20230348510-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-11-02 US disclosed
US-20230345812-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-10-26 US disclosed
US-20230345811-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-10-26 US disclosed
US-20230337521-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-10-19 US disclosed
US-20230337522-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-10-19 US disclosed
US-20230331756-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-10-19 US disclosed
US-20230337523-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-10-19 US disclosed
US-20230263049-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-08-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230337522-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES L1CAM, EML4, LBR NPC1 1803/4885RXFP1 3192/4885PTPN1 1789/4885
US-20230345812-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD1, OPRD1, OCIAD2 NPC1 2835/4885RXFP1 90/4885PTPN1 3478/4885
US-20230357296-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OPRD1, OXER1, LBR NPC1 1942/4885RXFP1 116/4885PTPN1 2840/4885
US-20230337523-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES LBR, OCIAD1, OCIAD2 NPC1 2775/4885RXFP1 131/4885PTPN1 4191/4885
US-20230331756-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES L1CAM, SSB, LBR NPC1 1856/4885RXFP1 503/4885PTPN1 2009/4885
US-20230337521-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD1, OCIAD2, NR1H2 NPC1 2199/4885RXFP1 745/4885PTPN1 4691/4885
US-20230263049-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OSBPL3, OCIAD1, OSBP NPC1 1370/4885RXFP1 4160/4885PTPN1 4586/4885
US-20230348510-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES LBR, OXER1, OXSR1 NPC1 2404/4885RXFP1 364/4885PTPN1 3517/4885
US-20230371358-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES LIFR, SOD1, ROS1 NPC1 4515/4885RXFP1 770/4885PTPN1 4057/4885
US-20230365606-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OXER1, OPRD1, OXSR1 NPC1 3499/4885RXFP1 228/4885PTPN1 3318/4885
US-20230345811-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OPRD1, L1CAM, OPRM1 NPC1 1706/4885RXFP1 1967/4885PTPN1 4307/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.