Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.36 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16090946 | 0.83 | LMNA (0.45) | L3MBTL1NPC1MITFLMNATP53 | |
| SCHEMBL11528658 | 0.81 | THRB (0.49) | L3MBTL1NPC1MITFLMNATP53 | |
| SCHEMBL29177490 | 0.76 | L3MBTL1 (0.51) | L3MBTL1NPC1MITFLMNATP53 | |
| SCHEMBL27739460 | 0.76 | L3MBTL1 (0.51) | L3MBTL1NPC1MITFLMNATP53 | |
| SCHEMBL26033225 | 0.76 | MEN1 (0.69) | LMNASMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL28748119 | 0.74 | KDM4E (0.56) | L3MBTL1NPC1MITFLMNATP53 | |
| SCHEMBL26032555 | 0.72 | ALDH1A1 (0.43) | SMN1; SMN2KMT2ATSHRKDM4EALDH1A1 | |
| SCHEMBL9752736 | 0.71 | L3MBTL1 (0.60) | L3MBTL1NPC1MITFLMNATP53 | |
| SCHEMBL21334490 | 0.70 | LMNA (0.49) | L3MBTL1NPC1MITFLMNATP53 | |
| SCHEMBL9752573 | 0.70 | L3MBTL1 (0.58) | L3MBTL1NPC1MITFLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4230264-A2 | PRODRUGS OF FUMARATES AND THEIR USE IN TREATING VARIOUS DESEASES | Alkermes Pharma Ireland Limited (IE) | 2023-08-23 | — | — | EP | disclosed |