Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 4/20 | 0.66 |
| ▸ | NOX1 | Q9Y5S8 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9419165 | 0.79 | NOX1 (0.82) | SNCANOX1MEN1ADRA2AADRA2B | |
| SCHEMBL29214097 | 0.73 | NOX1 (0.77) | SNCANOX1MEN1ADRA2AADRA2B | |
| SCHEMBL628732 | 0.71 | NOX1 (1.00) | SNCANOX1MEN1ADRA2AADRA2B | |
| SCHEMBL7389154 | 0.69 | SNCA (0.81) | SNCANOX1MEN1ADRA2AADRA2B | |
| SCHEMBL30019459 | 0.69 | MAPT (0.52) | MEN1ADRA2CDRD3KMT2AL3MBTL1 | |
| SCHEMBL10187265 | 0.68 | PARP10 (0.60) | PARP10BTKTNK2ACACBMAOA | |
| SCHEMBL21771119 | 0.67 | SNCA (0.71) | SNCAMEN1KMT2ALMNACYP2D6 | |
| SCHEMBL21771496 | 0.66 | SNCA (0.50) | SNCANOX1MEN1SLC6A2SLC6A4 | |
| SCHEMBL30019147 | 0.66 | MAPT (0.52) | MEN1ADRA2CDRD3KMT2AL3MBTL1 | |
| SCHEMBL14999402 | 0.66 | CYP3A4 (0.50) | SLC6A2SLC6A4PARP10IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11707452-B2 | Modulators of alpha-synuclein proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11707452-B2 | Modulators of alpha-synuclein proteolysis and associated methods of use | UCHL1, ADRM1, CRBN | SNCA 8/4885NOX1 2360/4885MEN1 3483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.