Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26039646 | 0.86 | — | — | |
| SCHEMBL26039645 | 0.85 | SIGMAR1 (0.33) | — | |
| SCHEMBL25357773 | 0.84 | OPRD1 (0.33) | REV1OPRD1OPRK1 | |
| SCHEMBL25354788 | 0.83 | OPRM1 (0.33) | OPRD1 | |
| SCHEMBL26039316 | 0.83 | SIGMAR1 (0.31) | — | |
| SCHEMBL25360960 | 0.82 | F2R (0.31) | OPRD1OPRK1 | |
| SCHEMBL26039260 | 0.81 | OPRL1 (0.31) | — | |
| SCHEMBL26039578 | 0.81 | — | — | |
| SCHEMBL26039259 | 0.81 | OPRM1 (0.33) | — | |
| SCHEMBL26039381 | 0.81 | OPRL1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154344-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |