Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 12/20 | 0.81 |
| ▸ | CHRM3 | P20309 | 12/20 | 0.81 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.79 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.79 |
| ▸ | MEN1 | O00255 | 2/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | MITF | O75030 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.62 |
| ▸ | CA12 | O43570 | 1/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | CA4 | P22748 | 1/20 | 0.62 |
| ▸ | CA5A | P35218 | 1/20 | 0.62 |
| ▸ | CA7 | P43166 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6045571 | 0.88 | OPRM1 (1.00) | CHRM2CHRM3OPRM1SIGMAR1MEN1 | |
| SCHEMBL21143168 | 0.87 | SIGMAR1 (0.64) | CHRM2CHRM3OPRM1SIGMAR1MEN1 | |
| Hydrochloric Acid SCHEMBL29651340 | 0.87 | OPRM1 (0.97) | CHRM2CHRM3OPRM1SIGMAR1MEN1 | |
| SCHEMBL27332898 | 0.86 | OPRM1 (0.77) | CHRM2CHRM3OPRM1SIGMAR1MEN1 | |
| Oxalic Acid SCHEMBL6045624 | 0.86 | OPRM1 (0.95) | CHRM2CHRM3OPRM1SIGMAR1MEN1 | |
| SCHEMBL6045443 | 0.85 | CHRM2 (0.83) | CHRM2CHRM3OPRM1SIGMAR1MEN1 | |
| SCHEMBL18770884 | 0.85 | MITF (0.71) | CHRM2CHRM3OPRM1SIGMAR1MEN1 | |
| SCHEMBL19953554 | 0.84 | ALDH1A1 (0.84) | CHRM2CHRM3OPRM1SIGMAR1MEN1 | |
| SCHEMBL31255945 | 0.84 | CHRM2 (1.00) | CHRM2CHRM3OPRM1SIGMAR1MEN1 | |
| SCHEMBL15848501 | 0.84 | CHRM2 (0.72) | CHRM2CHRM3OPRM1SIGMAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252815-B2 | Nociceptin analogs | PURDUE PHARMA L.P. (US) | 2012-08-28 | — | — | US | disclosed |
| US-8252815-B2 | Nociceptin analogs | PURDUE PHARMA L.P. (US) | 2012-08-28 | — | — | US | disclosed |
| US-20120095049-A1 | NOCICEPTIN ANALOGS | PURDUE PHARMA L.P. (US) | 2012-04-19 | — | — | US | disclosed |
| US-20120095049-A1 | NOCICEPTIN ANALOGS | PURDUE PHARMA L.P. (US) | 2012-04-19 | — | — | US | disclosed |
| US-7939670-B2 | Nociceptin analogs | PURDUE PHARMA L.P. (US) | 2011-05-10 | — | — | US | disclosed |
| US-7939670-B2 | Nociceptin analogs | PURDUE PHARMA L.P. (US) | 2011-05-10 | — | — | US | disclosed |
| US-20090156640-A1 | NOCICEPTIN ANALOGS | EURO-CELTIQUE S.A. | 2009-06-18 | — | — | US | disclosed |
| US-20090156640-A1 | NOCICEPTIN ANALOGS | EURO-CELTIQUE S.A. | 2009-06-18 | — | — | US | disclosed |
| US-7495109-B2 | Nociceptin analogs | PURDUE PHARMA L.P. (US) | 2009-02-24 | — | — | US | disclosed |
| US-7495109-B2 | Nociceptin analogs | PURDUE PHARMA L.P. (US) | 2009-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156640-A1 | NOCICEPTIN ANALOGS | OPRL1, NPY1R, NPBWR1 | CHRM2 369/4885CHRM3 301/4885OPRM1 8/4885 |
| US-20120095049-A1 | NOCICEPTIN ANALOGS | OPRL1, NPY1R, NPBWR1 | CHRM2 369/4885CHRM3 301/4885OPRM1 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.