Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | RXRA | P19793 | 3/20 | 0.44 |
| ▸ | RXRB | P28702 | 3/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16178565 | 0.84 | SMN1; SMN2 (0.79) | SMN1; SMN2L3MBTL1MAPTHPGDRXRA | |
| SCHEMBL12518234 | 0.84 | ACHE (0.45) | SMN1; SMN2L3MBTL1MAPTHPGDALDH1A1 | |
| SCHEMBL26054420 | 0.83 | MAPT (0.56) | SMN1; SMN2MAPTRXRARXRBLMNA | |
| SCHEMBL25736529 | 0.83 | RXRA (0.64) | RXRARXRBBCL2LMNAKMO | |
| SCHEMBL14226740 | 0.82 | KMO (0.60) | SMN1; SMN2MAPTRXRARXRBERCC5 | |
| SCHEMBL14226767 | 0.81 | DHODH (0.51) | MAPTRXRARXRBLMNAKMO | |
| SCHEMBL5972998 | 0.80 | MAPT (0.53) | SMN1; SMN2L3MBTL1MAPTHPGDKDM4E | |
| SCHEMBL6570603 | 0.80 | SMN1; SMN2 (0.66) | SMN1; SMN2L3MBTL1MAPTHPGDRXRA | |
| SCHEMBL14226746 | 0.80 | KAT6A (0.47) | RXRARXRBLMNAKMO | |
| SCHEMBL15131310 | 0.80 | KMO (0.62) | SMN1; SMN2MAPTRXRARXRBBCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11731967-B2 | Inhibitors of TRIM33 and methods of use | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11731967-B2 | Inhibitors of TRIM33 and methods of use | TRIM33, TRIM28, TRIM4 | SMN1; SMN2 639/4885L3MBTL1 487/4885MAPT 1086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.