Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 3/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.42 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26100658 | 0.93 | EGFR (0.45) | EGFRKDRPSEN1PSEN2APH1B | |
| SCHEMBL26102254 | 0.84 | PDK1 (0.51) | KDRPSEN1PDK1BRAFKIT | |
| SCHEMBL26100799 | 0.84 | PDK1 (0.51) | KDRPSEN1PDK1BRAFKIT | |
| SCHEMBL26100106 | 0.84 | RXRA (0.46) | EGFRKDRPDK1KDM1ABRAF | |
| SCHEMBL26098271 | 0.83 | EGFR (0.46) | EGFRKDRPDK1KDM1ABRAF | |
| SCHEMBL30394612 | 0.83 | EGFR (0.54) | EGFRKDRBRAFIRAK4RAF1 | |
| SCHEMBL26102818 | 0.83 | EGFR (0.54) | EGFRKDRBRAFIRAK4KIT | |
| SCHEMBL26098276 | 0.83 | EGFR (0.54) | EGFRKDRBRAFIRAK4RAF1 | |
| SCHEMBL26099737 | 0.81 | BRAF (0.46) | KDRBRAFIRAK4KITRAF1 | |
| SCHEMBL30394282 | 0.80 | KIT (0.43) | EGFRKDRBRAFIRAK4KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023075529-A1 | QUINAZOLINE DERIVATIVE COMPOUND AND USE THEREOF | 보로노이바이오 주식회사 | 2023-05-04 | — | — | WO | disclosed |