Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | TACR3 | P29371 | 1/20 | 0.48 |
| ▸ | MLNR | O43193 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26101890 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL23747566 | 0.87 | NAMPT (0.52) | SMN1; SMN2ALDH1A1TACR3MLNRCYP3A4 | |
| SCHEMBL23747807 | 0.87 | NAMPT (0.52) | SMN1; SMN2ALDH1A1TACR3MLNRCYP3A4 | |
| SCHEMBL26101112 | 0.81 | MLNR (0.48) | SMN1; SMN2ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL26101852 | 0.81 | GAA (0.51) | SMN1; SMN2ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL26097985 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL26100870 | 0.79 | HSD11B1 (0.51) | SMN1; SMN2ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL26100459 | 0.79 | HSD11B1 (0.51) | SMN1; SMN2ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL26102249 | 0.76 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1GAAMAPTGFER | |
| SCHEMBL23747788 | 0.74 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | NAMPT, MC4R, SIRT1 | SMN1; SMN2 1161/4885ALDH1A1 2019/4885KDM4E 2721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.