Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26100870 | 1.00 | HSD11B1 (0.51) | HSD11B1SMN1; SMN2GAAKDM4EMAPT | |
| SCHEMBL26103046 | 0.88 | HPGD (0.48) | MAPTL3MBTL1 | |
| SCHEMBL26102746 | 0.88 | HPGD (0.48) | MAPTL3MBTL1 | |
| SCHEMBL26097964 | 0.86 | RAB9A (0.53) | HSD11B1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL26102617 | 0.86 | RAB9A (0.53) | HSD11B1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL26103379 | 0.81 | HPGD (0.52) | HSD11B1MAPTCYP3A4 | |
| SCHEMBL23747432 | 0.80 | NAMPT (0.52) | HSD11B1SMN1; SMN2ALOX12ALDH1A1POLB | |
| SCHEMBL26132756 | 0.80 | NAMPT (0.52) | HSD11B1SMN1; SMN2ALOX12ALDH1A1POLB | |
| SCHEMBL26100141 | 0.79 | SMN1; SMN2 (0.51) | HSD11B1SMN1; SMN2GAAKDM4EMAPT | |
| SCHEMBL26101890 | 0.79 | SMN1; SMN2 (0.51) | HSD11B1SMN1; SMN2GAAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | NAMPT, MC4R, SIRT1 | HSD11B1 1658/4885SMN1; SMN2 1161/4885GAA 2947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.