Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.44 |
| ▸ | HTR2C | P28335 | 4/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | HTR2B | P41595 | 3/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1E | P28566 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26105691 | 0.80 | PARP1 (0.41) | HTR2AHTR2CHTR1AHTR2BHTR6 | |
| SCHEMBL30392698 | 0.80 | PARP1 (0.41) | HTR2AHTR2CHTR1AHTR2BHTR6 | |
| SCHEMBL21510708 | 0.70 | PARP1 (0.49) | HTR2AHTR2CHTR1AHTR2BHTR6 | |
| SCHEMBL6311706 | 0.69 | PARP1 (0.48) | HTR2AHTR2CHTR1AHTR2BHTR6 | |
| SCHEMBL6307694 | 0.67 | HTR2A (0.43) | HTR2AHTR2CHTR1AHTR2BHTR6 | |
| SCHEMBL22680195 | 0.66 | HTR1A (0.39) | HTR2AHTR2CHTR1AHTR2BHTR6 | |
| SCHEMBL8798234 | 0.65 | PRKCD (0.58) | HTR2AHTR2CHTR1AHTR2BHTR6 | |
| SCHEMBL9483531 | 0.65 | PARP1 (0.54) | HTR2AHTR2CHTR1AHTR2BHTR6 | |
| SCHEMBL18086991 | 0.64 | KDM4E (0.53) | HTR2AHTR2CHTR1AHTR2BHTR6 | |
| SCHEMBL8798488 | 0.63 | PARP1 (0.44) | HTR2AHTR2CHTR1AHTR2BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4423084-A1 | ERGOLINE-DERIVED AGONISTS OF THE 5-HT2A RECEPTOR | Diamond Therapeutics Inc. (CA) | 2024-09-04 | — | — | EP | disclosed |
| US-20240279226-A1 | ERGOLINE-DERIVED AGONISTS OF THE 5-HT2A RECEPTOR | DIAMOND THERAPEUTICS INC. (CA) | 2024-08-22 | — | — | US | disclosed |
| WO-2023073423-A1 | ERGOLINE-DERIVED AGONISTS OF THE 5-HT2A RECEPTOR | DIAMOND THERAPEUTICS INC. (CA) | 2023-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240279226-A1 | ERGOLINE-DERIVED AGONISTS OF THE 5-HT2A RECEPTOR | HTR2A, HTR2B, HTR2C | HTR2A 1/4885HTR2C 3/4885HTR1A 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.