Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26103963 | 0.83 | MAPT (0.47) | MAPTGABRA2GABRB2KDM4EPOLB | |
| SCHEMBL26502927 | 0.81 | MAPT (0.46) | MAPTGABRA2GABRB2KDM4EPOLB | |
| SCHEMBL24114810 | 0.77 | NPC1 (0.48) | MAPTGABRA2GABRB2KDM4EPOLB | |
| SCHEMBL5317799 | 0.76 | TRPM8 (0.49) | MAPTGABRA2GABRB2KDM4EPOLB | |
| SCHEMBL1255641 | 0.74 | PRKCZ (0.50) | MAPTGABRA2GABRB2KDM4EPOLB | |
| SCHEMBL23757849 | 0.74 | KDM4E (0.50) | MAPTKDM4EPOLBHTTALDH1A1 | |
| SCHEMBL14705878 | 0.73 | GCGR (0.49) | MAPTGABRA2GABRB2KDM4EPOLB | |
| SCHEMBL20075637 | 0.73 | GABRA2 (0.43) | MAPTGABRA2GABRB2KDM4EPOLB | |
| SCHEMBL16260565 | 0.72 | KDM4E (0.57) | MAPTKDM4EPOLBLMNANPC1 | |
| SCHEMBL8364027 | 0.72 | TSHR (0.52) | MAPTGABRA2GABRB2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023076849-A1 | INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR | ORIC PHARMACEUTICALS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |