Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | PYGL | P06737 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | G6PD | P11413 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26505052 | 0.81 | RAB9A (0.52) | NPC1RAB9APYGLMEN1KMT2A | |
| SCHEMBL31668441 | 0.81 | RAB9A (0.52) | NPC1RAB9APYGLMEN1KMT2A | |
| SCHEMBL21423113 | 0.74 | RAB9A (0.53) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL9646962 | 0.72 | KCNMA1 (0.64) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL26106853 | 0.72 | RAB9A (0.61) | NPC1RAB9APYGLMAPTMEN1 | |
| SCHEMBL30774378 | 0.71 | RAB9A (0.60) | NPC1RAB9APYGLMAPTMEN1 | |
| SCHEMBL29161484 | 0.71 | RAB9A (0.60) | NPC1RAB9APYGLMAPTMEN1 | |
| SCHEMBL5647147 | 0.70 | PKM (0.55) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL9414162 | 0.69 | APP (0.63) | NPC1RAB9APYGLMAPTMEN1 | |
| SCHEMBL21422973 | 0.69 | MAPT (0.54) | NPC1RAB9AMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250243188-A1 | METHIONINE ADENOSYLTRANSERASE 2A INHIBITORS | IDEAYA BIOSCIENCES, INC. | 2025-07-31 | — | — | US | disclosed |
| WO-2023196985-A1 | METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250243188-A1 | METHIONINE ADENOSYLTRANSERASE 2A INHIBITORS | MAT2A, MAT2B, MAT1A | NPC1 3170/4885RAB9A 1337/4885PYGL 614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.