Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | PHPT1 | Q9NRX4 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11791019 | 0.80 | MAPT (0.56) | MAPTNPC1RAB9APOLBKDM4E | |
| SCHEMBL27931526 | 0.79 | NPC1 (0.54) | MAPTNPC1RAB9APOLBKDM4E | |
| SCHEMBL12845563 | 0.77 | HDAC1 (0.44) | MAPTNPC1RAB9APOLBKDM4E | |
| SCHEMBL7964816 | 0.77 | HDAC1 (0.55) | MAPTNPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL2896946 | 0.77 | POLB (0.71) | MAPTNPC1RAB9APOLBKDM4E | |
| SCHEMBL11720879 | 0.77 | POLB (1.00) | MAPTNPC1RAB9APOLBKDM4E | |
| SCHEMBL4958020 | 0.76 | MAPT (0.69) | MAPTNPC1RAB9APOLBKDM4E | |
| SCHEMBL4520067 | 0.76 | NPC1 (0.69) | MAPTNPC1RAB9APOLBKDM4E | |
| SCHEMBL12510786 | 0.74 | ALDH1A1 (0.54) | MAPTNPC1RAB9AKDM4ELMNA | |
| SCHEMBL4668944 | 0.74 | MAPT (0.67) | MAPTNPC1RAB9APOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101116-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS KINASES INHIBITORS AND METHODS OF USE THEREOF | MEDOLUTION LIMITED (US) | 2012-04-26 | — | — | US | disclosed |
| US-7982043-B2 | Protein tyrosine kinase enzyme inhibitors | WYETH LLC (US) | 2011-07-19 | — | — | US | disclosed |
| US-20080319011-A1 | PROTEIN TYROSINE KINASE ENZYME INHIBITORS | WYETH (US) | 2008-12-25 | — | — | US | disclosed |
| US-7399865-B2 | such as (E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide used as antineoplastic agents, or inhibitors of the HER-2 gene or proteins and epidermal growth factor receptor enzymes | WYETH (US) | 2008-07-15 | — | — | US | disclosed |
| US-20080161575-A1 | Process for the synthesis of 6-amino-4-(3-chloro-4-fluorophenylamino)-7-ethoxyquinoline-3-carbonitrile | WYETH (US) | 2008-07-03 | — | — | US | disclosed |
| US-7365203-B2 | Process for the synthesis of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile | WYETH (US) | 2008-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161575-A1 | Process for the synthesis of 6-amino-4-(3-chloro-4-fluorophenylamino)-7-ethoxyquinoline-3-carbonitrile | QPCT, CYP3A4, CPNE4 | MAPT 3602/4885NPC1 2916/4885RAB9A 1577/4885 |
| US-20080319011-A1 | PROTEIN TYROSINE KINASE ENZYME INHIBITORS | ABL1, ERBB2, RET | MAPT 2203/4885NPC1 4631/4885RAB9A 1940/4885 |
| US-20120101116-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS KINASES INHIBITORS AND METHODS OF USE THEREOF | MAP4K2, MAP3K7, MAP3K1 | MAPT 2640/4885NPC1 3376/4885RAB9A 1012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.