Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.31 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.31 |
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.31 |
| ▸ | PARP1 | P09874 | 5/20 | 0.31 |
| ▸ | PARP11 | Q9NR21 | 3/20 | 0.31 |
| ▸ | NQO1 | P15559 | 1/20 | 0.31 |
| ▸ | F7 | P08709 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26123418 | 0.86 | NNMT (0.31) | NNMT | |
| SCHEMBL25363053 | 0.78 | CDC7 (0.43) | KDM4EPARP10PARP1PARP11NQO1 | |
| SCHEMBL26117612 | 0.74 | PARP10 (0.34) | USP2ALDH1A1MAPK1HTTTDP1 | |
| SCHEMBL26117215 | 0.73 | NOS3 (0.41) | — | |
| SCHEMBL25361875 | 0.72 | PNMT (0.31) | — | |
| SCHEMBL32680609 | 0.70 | L3MBTL1 (0.38) | ALDH1A1MAPK1KDM4E | |
| SCHEMBL30571590 | 0.70 | L3MBTL1 (0.36) | ALDH1A1MAPK1KDM4EDYRK1A | |
| SCHEMBL26119776 | 0.69 | — | — | |
| SCHEMBL13361329 | 0.66 | PARP10 (0.46) | KDM4EPARP10PARP1PARP11F7 | |
| SCHEMBL390545 | 0.66 | PARP10 (0.46) | MAPK1KDM4EMAP2K1PARP10PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044098-A2 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | ALEXION PHARMACEUTICALS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |
| WO-2023183405-A2 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | ALEXION PHARMACEUTICALS, INC. (US) | 2023-09-28 | — | — | WO | disclosed |