Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 9/20 | 0.74 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.74 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.74 |
| ▸ | GABRB2 | P47870 | 8/20 | 0.74 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.74 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.74 |
| ▸ | HPGD | P15428 | 3/20 | 0.74 |
| ▸ | BRD4 | O60885 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | CNR1 | P21554 | 1/20 | 0.74 |
| ▸ | PTAFR | P25105 | 4/20 | 0.60 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13285201 | 0.93 | GABRA5 (0.63) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11620188 | 0.87 | PTAFR (0.79) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL10696328 | 0.85 | GABRA1 (0.78) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| Alprazolam SCHEMBL29381667 | 0.85 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL29363349 | 0.85 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| Alprazolam SCHEMBL8398 | 0.85 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL8250450 | 0.85 | GABRA1 (0.74) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11839951 | 0.85 | GABRA1 (0.61) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| Alprazolam SCHEMBL16922178 | 0.85 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| Alprazolam SCHEMBL5480614 | 0.85 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRB2GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095217-A1 | FLUORINE CONTAINING COMPOUNDS AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2012-04-19 | — | — | US | disclosed |
| US-20120095217-A1 | FLUORINE CONTAINING COMPOUNDS AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2012-04-19 | — | — | US | disclosed |
| WO-2010081036-A2 | FLUORINE CONTAINING COMPOUNDS AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095217-A1 | FLUORINE CONTAINING COMPOUNDS AND METHODS OF USE THEREOF | FLI1, CDC73, FOS | GABRA1 1880/4885GABRA5 2062/4885GABRA2 2102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.