Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JMJD6 | Q6NYC1 | 2/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.38 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 4/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31512085 | 0.94 | JMJD6 (0.38) | JMJD6BMPR1AACVRL1ACVR1IRAK4 | |
| SCHEMBL31512068 | 0.78 | ALOX5AP (0.43) | JMJD6BMPR1AACVRL1ACVR1IRAK4 | |
| SCHEMBL26193347 | 0.77 | JMJD6 (0.37) | JMJD6BMPR1AACVRL1ACVR1IRAK4 | |
| SCHEMBL26193404 | 0.77 | BMPR1A (0.40) | JMJD6BMPR1AACVRL1ACVR1IRAK4 | |
| SCHEMBL25261218 | 0.77 | HPGDS (0.42) | JMJD6ALOX5APFEN1 | |
| SCHEMBL26193402 | 0.76 | JMJD6 (0.36) | JMJD6BMPR1AACVRL1ACVR1IRAK4 | |
| SCHEMBL26193351 | 0.74 | JMJD6 (0.40) | JMJD6BMPR1AACVRL1ACVR1IRAK4 | |
| SCHEMBL30510170 | 0.74 | S1PR2 (0.38) | JMJD6IRAK4MAPK10CREBBPS1PR2 | |
| SCHEMBL25302815 | 0.74 | S1PR2 (0.38) | JMJD6IRAK4MAPK10CREBBPS1PR2 | |
| Hydrochloric Acid SCHEMBL31415289 | 0.71 | KEAP1 (0.44) | JMJD6BMPR1AACVRL1ACVR1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030866-B2 | 2-pyrazole anilines and related analogs for inhibiting YAP/TAZ-TEAD | SPRINGWORKS THERAPEUTICS, INC. (US) | 2024-07-09 | — | — | US | disclosed |
| US-20230278982-A1 | 2-Pyrazole Anilines and Related Analogs for Inhibiting YAP/TAZ-TEAD | KU LEUVEN R&D (BE) | 2023-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230278982-A1 | 2-Pyrazole Anilines and Related Analogs for Inhibiting YAP/TAZ-TEAD | YAP1, TEAD3, TEAD2 | JMJD6 916/4885BMPR1A 2383/4885ACVRL1 2371/4885 |
| US-12030866-B2 | 2-pyrazole anilines and related analogs for inhibiting YAP/TAZ-TEAD | YAP1, TEAD3, TEAD2 | JMJD6 916/4885BMPR1A 2383/4885ACVRL1 2371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.