Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.48 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.47 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.47 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.42 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CPA1 | P15085 | 2/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LAP3 | P28838 | 3/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL262005 | 1.00 | SLC7A5 (0.48) | SLC7A5CACNA2D1CACNB3CACNA1CPGR | |
| SCHEMBL20953995 | 0.85 | RNPEP (0.50) | SLC7A5CACNA2D1CACNB3CACNA1CPGR | |
| SCHEMBL12344527 | 0.82 | SLC7A5 (0.48) | SLC7A5CACNA2D1CACNB3CACNA1CPGR | |
| SCHEMBL15710292 | 0.76 | GABRR1 (0.36) | SLC7A5CACNA2D1CACNB3CACNA1CPGR | |
| SCHEMBL18992175 | 0.72 | CACNA2D1 (0.42) | SLC7A5CACNA2D1CACNB3CACNA1CPGR | |
| SCHEMBL2824755 | 0.72 | GRIK1 (0.40) | SLC7A5RNPEPSLC1A3SLC1A2ALDH1A1 | |
| SCHEMBL29950790 | 0.71 | SLC1A3 (0.61) | SLC7A5CACNA2D1CACNB3CACNA1CPGR | |
| SCHEMBL1058202 | 0.71 | SLC1A3 (0.61) | SLC7A5CACNA2D1CACNB3CACNA1CPGR | |
| SCHEMBL4738612 | 0.71 | SLC1A3 (0.61) | SLC7A5CACNA2D1CACNB3CACNA1CPGR | |
| SCHEMBL1409156 | 0.71 | CPA1 (0.61) | SLC7A5RNPEPSLC1A3SLC1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831154-B1 | PREPARATION OF PREGABALIN AND RELATED COMPOUNDS | WARNER LAMBERT CO (US) | 2010-01-13 | — | — | EP | claimed |
| US-20090042262-A1 | Preparation of Pregabalin and Related Compounds | PFIZER INC | 2009-02-12 | — | — | US | claimed |
| EP-1831154-A2 | PREPARATION OF PREGABALIN AND RELATED COMPOUNDS | Warner-Lambert Company LLC (US) | 2007-09-12 | — | — | EP | claimed |
| WO-2006000904-A2 | PREPARATION OF PREGABALIN AND RELATED COMPOUNDS | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-05 | — | — | WO | claimed |
| US-20050283023-A1 | Preparation of pregabalin and related compounds | HU SHANGHUI | 2005-12-22 | — | — | US | claimed |
| US-8134023-B2 | Preparation of pregabalin and related compounds | PFIZER INC (US) | 2012-03-13 | — | — | US | disclosed |
| US-20120015412-A1 | Preparation of Pregabalin and Related Compounds | PFIZER INC | 2012-01-19 | — | — | US | disclosed |
| US-8044227-B2 | Preparation of pregabalin and related compounds | PFIZER INC. (US) | 2011-10-25 | — | — | US | disclosed |
| US-20110245508-A1 | Processes For Making Pregabalin And Intermediates Therefor | THIJS LAMBERTUS | 2011-10-06 | — | — | US | disclosed |
| US-20110245508-A1 | Processes For Making Pregabalin And Intermediates Therefor | THIJS LAMBERTUS | 2011-10-06 | — | — | US | disclosed |
| US-20110065168-A1 | Preparation of Pregabalin and Related Compounds | PFIZER INC | 2011-03-17 | — | — | US | disclosed |
| US-7838686-B2 | Preparation of pregabalin and related compounds | PFIZER INC. (US) | 2010-11-23 | — | — | US | disclosed |
| EP-1831154-B1 | PREPARATION OF PREGABALIN AND RELATED COMPOUNDS | WARNER LAMBERT CO (US) | 2010-01-13 | — | — | EP | disclosed |
| US-20090312560-A1 | PROCESSES FOR MAKING PREGABALIN AND INTERMEDIATES THEREFOR | SYNTHON BV (NL) | 2009-12-17 | — | — | US | disclosed |
| US-20090312560-A1 | PROCESSES FOR MAKING PREGABALIN AND INTERMEDIATES THEREFOR | SYNTHON BV (NL) | 2009-12-17 | — | — | US | disclosed |
| WO-2009149928-A1 | PROCESSES FOR MAKING PREGABALIN AND INTERMEDIATES THEREFOR | SYNTHON B.V. (NL) | 2009-12-17 | — | — | WO | disclosed |
| US-20090042262-A1 | Preparation of Pregabalin and Related Compounds | PFIZER INC | 2009-02-12 | — | — | US | disclosed |
| EP-1831154-A2 | PREPARATION OF PREGABALIN AND RELATED COMPOUNDS | Warner-Lambert Company LLC (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006000904-A2 | PREPARATION OF PREGABALIN AND RELATED COMPOUNDS | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-05 | — | — | WO | disclosed |
| US-20050283023-A1 | Preparation of pregabalin and related compounds | HU SHANGHUI | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042262-A1 | Preparation of Pregabalin and Related Compounds | GABRE, GABRG1, GABRA6 | SLC7A5 1853/4885CACNA2D1 148/4885CACNB3 118/4885 |
| US-20050283023-A1 | Preparation of pregabalin and related compounds | GABRE, GABRG1, GABRA6 | SLC7A5 1853/4885CACNA2D1 148/4885CACNB3 118/4885 |
| US-20110245508-A1 | Processes For Making Pregabalin And Intermediates Therefor | GABRB2, GABRB1, GABRB3 | SLC7A5 2553/4885CACNA2D1 638/4885CACNB3 378/4885 |
| US-20110065168-A1 | Preparation of Pregabalin and Related Compounds | GABRE, GABRG1, GABRA6 | SLC7A5 1853/4885CACNA2D1 148/4885CACNB3 118/4885 |
| US-20090312560-A1 | PROCESSES FOR MAKING PREGABALIN AND INTERMEDIATES THEREFOR | GABRB2, GABRB1, GABRB3 | SLC7A5 2553/4885CACNA2D1 638/4885CACNB3 378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.