Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | LDHA | P00338 | 1/20 | 0.31 |
| ▸ | LDHB | P07195 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13857056 | 0.87 | ALDH1A1 (0.33) | ALDH1A1AKR1B1 | |
| SCHEMBL13857053 | 0.79 | LDHA (0.44) | ALBLDHALDHBKDM4EALDH1A1 | |
| SCHEMBL1144495 | 0.68 | ALB (0.31) | ALBLDHALDHBKDM4EALDH1A1 | |
| SCHEMBL7186216 | 0.66 | LDHA (0.62) | ALBLDHALDHBKDM4EALDH1A1 | |
| SCHEMBL1144454 | 0.66 | AKR1B1 (0.33) | AKR1B1 | |
| SCHEMBL29141732 | 0.63 | HSD17B10 (0.54) | KDM4EALDH1A1HSD17B10 | |
| SCHEMBL2622272 | 0.63 | ALB (0.65) | ALBLDHALDHBKDM4EALDH1A1 | |
| SCHEMBL8460263 | 0.63 | LDHA (0.65) | ALBLDHALDHBKDM4EALDH1A1 | |
| Gossypolone SCHEMBL2622243 | 0.63 | AKR1B1 (0.44) | ALBLDHALDHBKDM4EALDH1A1 | |
| Gossypolone SCHEMBL29407306 | 0.63 | AKR1B1 (0.44) | ALBLDHALDHBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163805-B2 | Small molecule antagonists of Bcl-2 family proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163805-B2 | Small molecule antagonists of Bcl-2 family proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-04-24 | — | — | US | disclosed |
| US-20100069344-A1 | SMALL MOLECULE ANTAGONISTS OF BCL2 FAMILY PROTEINS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-03-18 | — | — | US | disclosed |
| US-20100069344-A1 | SMALL MOLECULE ANTAGONISTS OF BCL2 FAMILY PROTEINS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-03-18 | — | — | US | disclosed |
| US-20090118377-A1 | APOGOSSYPOLONE AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-05-07 | — | — | US | disclosed |
| US-20090118377-A1 | APOGOSSYPOLONE AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-05-07 | — | — | US | disclosed |
| US-20090092684-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | GEORGETOWN UNIVERSITY | 2009-04-09 | — | — | US | disclosed |
| US-20090092684-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | GEORGETOWN UNIVERSITY | 2009-04-09 | — | — | US | disclosed |
| US-20090082424-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | REGENTS OF THE UNIVERSITY OF MICHIGAN, THE | 2009-03-26 | — | — | US | disclosed |
| US-20090082424-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | REGENTS OF THE UNIVERSITY OF MICHIGAN, THE | 2009-03-26 | — | — | US | disclosed |
| US-7432304-B2 | Small molecule antagonists of Bcl-2 family proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432304-B2 | Small molecule antagonists of Bcl-2 family proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090092684-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | BCL2, BCL2L1, BCL2L2 | ALB 4624/4885LDHA 3274/4885LDHB 3231/4885 |
| US-20100069344-A1 | SMALL MOLECULE ANTAGONISTS OF BCL2 FAMILY PROTEINS | BCL2L1, BCL2, BCL2L11 | ALB 4693/4885LDHA 2995/4885LDHB 2689/4885 |
| US-20090118377-A1 | APOGOSSYPOLONE AND THE USES THEREOF | BCL2, BAD, BAX | ALB 4294/4885LDHA 4346/4885LDHB 3645/4885 |
| US-20090082424-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | BCL2, BCL2L1, BCL2L2 | ALB 4624/4885LDHA 3274/4885LDHB 3231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.