Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CDC25C | P30307 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26239253 | 0.89 | KCNH2 (0.61) | KCNH2ALDH1A1CDC25CMEN1THRB | |
| SCHEMBL26239268 | 0.84 | KCNH2 (0.54) | KCNH2CDC25CMEN1THRBAPEX1 | |
| SCHEMBL10721556 | 0.81 | KCNH2 (0.62) | KCNH2CDC25CMEN1THRBAPEX1 | |
| SCHEMBL26239281 | 0.80 | KCNH2 (0.49) | KCNH2CDC25CMEN1THRBAPEX1 | |
| SCHEMBL6572919 | 0.78 | KCNH2 (0.61) | KCNH2CDC25CMEN1THRBAPEX1 | |
| SCHEMBL732933 | 0.78 | TP53 (0.55) | ALDH1A1KMT2ATDP1TP53HTT | |
| SCHEMBL3929250 | 0.78 | KCNH2 (1.00) | KCNH2CDC25CSIGMAR1GAA | |
| SCHEMBL5047690 | 0.77 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2ATDP1TP53 | |
| SCHEMBL7702574 | 0.77 | KCNH2 (0.69) | KCNH2ALDH1A1CDC25CMEN1THRB | |
| SCHEMBL6573041 | 0.76 | CYP1A2 (0.55) | KCNH2CDC25CMEN1THRBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025846-A1 | ULTRA SHORT ACTING ANTI-ARRHYTHMIC AGENTS | ACAD PHARMACEUTICALS INC (US) | 2024-01-25 | — | — | US | disclosed |
| US-11731938-B2 | Ultra short acting anti-arrhythmic agents | ACADEMIC PHARMACEUTICALS INC (US) | 2023-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11731938-B2 | Ultra short acting anti-arrhythmic agents | CACNA1G, SCN5A, CACNA1F | KCNH2 51/4885ALDH1A1 1515/4885CDC25C 3526/4885 |
| US-20240025846-A1 | ULTRA SHORT ACTING ANTI-ARRHYTHMIC AGENTS | CACNA1G, SCN5A, CACNA1F | KCNH2 51/4885ALDH1A1 1515/4885CDC25C 3526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.