SCHEMBL26291332

SCHEMBL26291332

FC(F)Oc1ccc(CBr)cc1C(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RXRA P19793 3/20 0.41
RXRB P28702 3/20 0.41
RXRG P48443 3/20 0.41
IDO1 P14902 2/20 0.35
SLC22A12 Q96S37 1/20 0.34
TRPA1 O75762 1/20 0.34
PPARG P37231 1/20 0.33
USP28 Q96RU2 1/20 0.33
USP25 Q9UHP3 1/20 0.33
S1PR1 P21453 1/20 0.33
ULK1 O75385 1/20 0.32
PDE4A P27815 1/20 0.32
PDE4B Q07343 1/20 0.32
PDE4C Q08493 1/20 0.32
PDE4D Q08499 1/20 0.32
KDM4E B2RXH2 1/20 0.32
ATM Q13315 1/20 0.32
SLC6A4 P31645 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23032636 0.83 RXRA (0.44) RXRARXRBRXRGIDO1SLC22A12
SCHEMBL26291337 0.83 RXRA (0.44) RXRARXRBRXRGIDO1PPARG
SCHEMBL29783248 0.79 S1PR1 (0.45) RXRARXRBRXRGS1PR1
SCHEMBL478021 0.79 S1PR1 (0.45) RXRARXRBRXRGS1PR1
SCHEMBL21223997 0.77 PDE4A (0.35) PDE4APDE4BPDE4CPDE4D
SCHEMBL17610745 0.77 PPARG (0.37) PPARGPDE4APDE4BPDE4CPDE4D
SCHEMBL30640901 0.77 PDE4A (0.35) PDE4APDE4BPDE4CPDE4D
SCHEMBL26291307 0.76 XDH (0.45) RXRARXRBRXRGS1PR1
SCHEMBL22077713 0.75 SYK (0.48) PDE4APDE4BPDE4CPDE4DSLC6A4
SCHEMBL6353922 0.75 CA2 (0.48) PPARGPDE4APDE4BPDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230295076-A1 ACETOPHENONE OXIME COMPOUND AND APPLICATION THEREOF MEDSHINE DISCOVERY INC. (CN) 2023-09-21 US disclosed
US-20230295076-A1 ACETOPHENONE OXIME COMPOUND AND APPLICATION THEREOF MEDSHINE DISCOVERY INC. (CN) 2023-09-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230295076-A1 ACETOPHENONE OXIME COMPOUND AND APPLICATION THEREOF CYP11B2, ALDH7A1, CYP11B1 RXRA 2685/4885RXRB 2004/4885RXRG 2880/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.