SCHEMBL2633257

SCHEMBL2633257

O=C(O)CCC(=O)NC(Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.41

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GNPAT O15228 1/20 0.41
ACE P12821 6/20 0.38
MME P08473 4/20 0.36
PIN1 Q13526 1/20 0.36
SLC6A5 Q9Y345 1/20 0.36
NAALAD2 Q9Y3Q0 1/20 0.36
FOLH1 Q04609 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19051472 0.92 SLC6A5 (0.39) GNPATACEMMEPIN1SLC6A5
SCHEMBL2633324 0.89 ACE (0.36) GNPATACEPIN1SLC6A5
SCHEMBL2633410 0.89 PARP1 (0.37) GNPATACEMME
SCHEMBL29071836 0.89 PIN1 (0.36) ACEPIN1SLC6A5
SCHEMBL29893883 0.89 PIN1 (0.34) ACEMMEPIN1SLC6A5NAALAD2
Carnosine SCHEMBL33769 0.88 ITGB3 (0.41) ACEPIN1SLC6A5
SCHEMBL4295456 0.88 ITGB3 (0.45) ACEPIN1SLC6A5
Carnosine SCHEMBL33768 0.88 ITGB3 (0.41) ACEPIN1SLC6A5
Carnosine SCHEMBL1161010 0.88 ITGB3 (0.41) ACEPIN1SLC6A5
SCHEMBL7780968 0.88 FNTA (0.37) ACEPIN1SLC6A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9668973-B2 Components for producing amphoteric liposomes MARINA BIOTECH, INC. (US) 2017-06-06 US disclosed
US-20150118291-A1 Amphoteric Liposome Formulation NOVOSOM VERWALTUNGS GMBH (DE) 2015-04-30 US disclosed
US-20140227345-A1 COMPONENTS FOR PRODUCING AMPHOTERIC LIPOSOMES MARINA BIOTECH, INC. (US) 2014-08-14 US disclosed
US-20140056970-A1 EFFICIENT METHOD FOR LOADING AMPHOTERIC LIPOSOMES WITH NUCLEIC ACID ACTIVE SUBSTANCES MARINA BIOTECH, INC. (US) 2014-02-27 US disclosed
US-8580297-B2 Components for producing amphoteric liposomes MARINA BIOTECH, INC. (US) 2013-11-12 US disclosed
US-8367628-B2 Amphoteric liposome formulation PRONAI THERAPEUTICS, INC. (US) 2013-02-05 US disclosed
US-8193246-B2 Lipids and lipid assemblies comprising transfection enhancer elements MARINA BIOTECH, INC. (US) 2012-06-05 US disclosed
US-20120100205-A1 COMPONENTS FOR PRODUCING AMPHOTERIC LIPOSOMES MARINA BIOTECH, INC. 2012-04-26 US disclosed
US-20120021042-A1 Efficient Method For Loading Amphoteric Liposomes With Nucleic Acid Active Substances MARINA BIOTECH, INC. 2012-01-26 US disclosed
US-20080306153-A1 Lipids and lipid assemblies comprising transfection enhancer elements CEQUENT PHARMACEUTICALS, INC. 2008-12-11 US disclosed
US-20080145413-A1 Lipids and lipid assemblies comprising transfection enhancer elements MARINA BIOTECH, INC. 2008-06-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080145413-A1 Lipids and lipid assemblies comprising transfection enhancer elements HNRNPH3, SREBF2, PHOSPHO1 GNPAT 2741/4885ACE 4346/4885MME 2411/4885
US-20080306153-A1 Lipids and lipid assemblies comprising transfection enhancer elements SREBF1, SREBF2, ELOVL1 GNPAT 2586/4885ACE 4246/4885MME 2489/4885
US-20150118291-A1 Amphoteric Liposome Formulation ANXA5, ANXA11, CLPTM1L GNPAT 275/4885ACE 4870/4885MME 3721/4885
US-20140227345-A1 COMPONENTS FOR PRODUCING AMPHOTERIC LIPOSOMES PHOSPHO1, SGMS1, CHMP4B GNPAT 513/4885ACE 4141/4885MME 1442/4885
US-20120021042-A1 Efficient Method For Loading Amphoteric Liposomes With Nucleic Acid Active Substances LIPA, ANXA7, ANXA1 GNPAT 486/4885ACE 3710/4885MME 2086/4885
US-20120100205-A1 COMPONENTS FOR PRODUCING AMPHOTERIC LIPOSOMES PHOSPHO1, SGMS1, CHMP4B GNPAT 513/4885ACE 4141/4885MME 1442/4885
US-20140056970-A1 EFFICIENT METHOD FOR LOADING AMPHOTERIC LIPOSOMES WITH NUCLEIC ACID ACTIVE SUBSTANCES LIPA, ANXA7, ANXA6 GNPAT 515/4885ACE 3762/4885MME 2128/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.