Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16148932 | 0.81 | ALOX5AP (0.43) | TSHRGABRG2GABRB3GABRA1GABRA5 | |
| SCHEMBL23559755 | 0.81 | OPRL1 (0.39) | TSHRGABRG2GABRB3GABRA1GABRA2 | |
| SCHEMBL27946473 | 0.81 | CYP1A2 (0.42) | TSHRGABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL19105552 | 0.81 | ALDH1A1 (0.42) | TSHRGABRG2GABRB3GABRA1GABRA2 | |
| SCHEMBL6131063 | 0.80 | ESR2 (0.47) | TSHRGABRG2GABRB3GABRA1GABRA5 | |
| SCHEMBL27928925 | 0.80 | NPC1 (0.53) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL12679751 | 0.79 | GABRG2 (0.43) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL7015125 | 0.79 | CCR1 (0.50) | TSHRGABRG2GABRB3GABRA1GABRA2 | |
| SCHEMBL8965456 | 0.77 | ALDH1A1 (0.39) | TSHRGABRG2GABRB3GABRA1GABRA5 | |
| SCHEMBL8359938 | 0.77 | ESR2 (0.44) | TSHRGABRG2GABRB3GABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303573-A1 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | Grünenthal GmbH (DE) | 2023-09-28 | — | — | US | disclosed |
| US-20230303573-A1 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | Grünenthal GmbH (DE) | 2023-09-28 | — | — | US | disclosed |
| CN-104560023-A | Organic electroluminescent material, preparation method of organic electroluminescent material and organic electroluminescent device | OCEANS KING LIGHTING SCIENCE | 2015-04-29 | — | — | CN | disclosed |
| CN-104342114-A | Organic electro-phosphorescent material and preparation method thereof, and organic electroluminescent device | OCEANS KING LIGHTING SCIENCE | 2015-02-11 | — | — | CN | disclosed |
| CN-104327829-A | Blue ray organic electroluminescent material and preparation method and application thereof | OCEANS KING LIGHTING SCIENCE | 2015-02-04 | — | — | CN | disclosed |
| CN-104327828-A | Blue ray organic electroluminescent material and preparation method and application thereof | OCEANS KING LIGHTING SCIENCE | 2015-02-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230303573-A1 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, OPRL1 | TSHR 2261/4885GABRG2 244/4885GABRB3 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.