SCHEMBL26348154

SCHEMBL26348154

NC(=O)N1CC(=O)Nc2cc(F)ccc21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
HTT P42858 2/20 0.46
PARP1 P09874 1/20 0.45
BRD4 O60885 2/20 0.45
CASP3 P42574 1/20 0.43
CASP2 P42575 1/20 0.43
LMNA P02545 2/20 0.42
NPSR1 Q6W5P4 1/20 0.42
KMT2A Q03164 2/20 0.42
MEN1 O00255 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.41
TUBB4A P04350 1/20 0.40
TUBB P07437 1/20 0.40
TUBA3C P0DPH7 1/20 0.40
TUBA1B P68363 1/20 0.40
TUBA4A P68366 1/20 0.40
TUBB4B P68371 1/20 0.40
TUBB3 Q13509 1/20 0.40
TUBB2A Q13885 1/20 0.40
TUBB8 Q3ZCM7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26338105 0.85 AMPD2 (0.40) ALDH1A1HTTPARP1BRD4AMPD2
SCHEMBL28102575 0.81 HTT (0.49) ALDH1A1HTTPARP1BRD4CASP3
SCHEMBL19960683 0.78 HTT (0.68) ALDH1A1HTTBRD4CASP3CASP2
SCHEMBL4783094 0.75 KMT2A (0.44) ALDH1A1KMT2AMEN1
SCHEMBL11445936 0.75 ALDH1A1 (0.51) ALDH1A1HTTPARP1BRD4CASP3
SCHEMBL14758409 0.72 TUBB4A (0.49) ALDH1A1HTTBRD4LMNAKMT2A
SCHEMBL9375313 0.70 ALDH1A1 (0.47) ALDH1A1HTTBRD4LMNANPSR1
SCHEMBL1836755 0.70 PARP1 (0.51) ALDH1A1PARP1CASP3CASP2LMNA
SCHEMBL9381334 0.70 HTT (0.71) ALDH1A1HTTBRD4LMNANPSR1
SCHEMBL31539452 0.69 MAPK1 (0.49) ALDH1A1HTTBRD4CASP3CASP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4249480-A1 DIPHENYLPYRAZOLE COMPOUND, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Northwest A&F University (CN) 2023-09-27 EP disclosed