Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9381334 | 0.77 | HTT (0.71) | ALDH1A1SMN1; SMN2RAB9AHTTBRD4 | |
| SCHEMBL14758419 | 0.76 | MAPT (0.45) | ALDH1A1SMN1; SMN2HTTBRD4LMNA | |
| SCHEMBL13150727 | 0.75 | CYP11B1 (0.53) | ALDH1A1OPRM1OPRL1KMT2AMEN1 | |
| SCHEMBL31083654 | 0.75 | CYP11B1 (0.53) | ALDH1A1OPRM1OPRL1KMT2AMEN1 | |
| SCHEMBL8882051 | 0.74 | CASP2 (0.40) | SMN1; SMN2NPC1GAARAB9AKMT2A | |
| SCHEMBL9380202 | 0.73 | POLB (0.39) | ALDH1A1OPRM1OPRL1MAPTTDP1 | |
| SCHEMBL26348154 | 0.70 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2HTTBRD4LMNA | |
| SCHEMBL6540694 | 0.70 | MAPK1 (0.46) | ALDH1A1SMN1; SMN2NPC1GAAMAPK1 | |
| SCHEMBL8316573 | 0.70 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2RAB9AOPRM1OPRL1 | |
| SCHEMBL24378179 | 0.68 | MAPK1 (0.43) | ALDH1A1SMN1; SMN2NPC1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590022-A1 | IMIDAZO 1,5-a]QUINOXALINES | PHARMACIA & UPJOHN COMPANY (US) | 1994-04-06 | — | — | EP | disclosed |