Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | CES1 | P23141 | 2/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7620046 | 0.88 | — | — | |
| SCHEMBL9720387 | 0.77 | ALDH1A1 (0.92) | ALDH1A1TSHRHIF1ATDP1MEN1 | |
| SCHEMBL165983 | 0.73 | ALDH1A1 (1.00) | ALDH1A1TSHRHIF1ATDP1MEN1 | |
| Hydrochloric Acid SCHEMBL10715580 | 0.70 | ALDH1A1 (0.92) | ALDH1A1TSHRHIF1ATDP1MEN1 | |
| SCHEMBL5025868 | 0.69 | ALDH1A1 (0.62) | ALDH1A1TSHRHIF1ATDP1MEN1 | |
| SCHEMBL28647953 | 0.67 | CES2 (0.38) | ALDH1A1TSHRHIF1ATDP1MEN1 | |
| SCHEMBL9164047 | 0.66 | S100A4 (0.55) | ALDH1A1TSHRHIF1ATDP1MEN1 | |
| Cyclooctane SCHEMBL3271413 | 0.65 | ALDH1A1 (0.79) | ALDH1A1TSHRHIF1ATDP1MEN1 | |
| SCHEMBL9418712 | 0.65 | — | — | |
| SCHEMBL11494558 | 0.61 | MEN1 (0.35) | ALDH1A1TSHRHIF1ATDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111868049-B | Process for preparing somatostatin modulators | 克林提克斯医药股份有限公司 | 2023-06-30 | — | — | CN | claimed |
| EP-3740475-B1 | PROCESS OF MAKING SOMATOSTATIN MODULATORS | CRINETICS PHARMACEUTICALS INC (US) | 2022-04-20 | — | — | EP | claimed |
| US-20210087165-A1 | PROCESS OF MAKING SOMATOSTATIN MODULATORS | Crinetics Pharmaceuticals, Inc. | 2021-03-25 | — | — | US | claimed |
| EP-3740475-A1 | PROCESS OF MAKING SOMATOSTATIN MODULATORS | Crinetics Pharmaceuticals, Inc. (US) | 2020-11-25 | — | — | EP | claimed |
| CN-111868049-A | Methods of making somatostatin modulators | 克林提克斯医药股份有限公司 | 2020-10-30 | — | — | CN | claimed |
| US-20200048219-A1 | PROCESS OF MAKING SOMATOSTATIN MODULATORS | Crinetics Pharmaceuticals, Inc. | 2020-02-13 | — | — | US | claimed |
| US-10464918-B2 | Process of making somatostatin modulators | Crinetics Pharmaceuticals, Inc. (US) | 2019-11-05 | — | — | US | claimed |
| WO-2019143718-A1 | PROCESS OF MAKING SOMATOSTATIN MODULATORS | Crinetics Pharmaceuticals, Inc. (US) | 2019-07-25 | — | — | WO | claimed |
| US-20190218202-A1 | PROCESS OF MAKING SOMATOSTATIN MODULATORS | Crinetics Pharmaceuticals, Inc. | 2019-07-18 | — | — | US | claimed |
| US-8471067-B2 | Stereoselective preparation of P-chiral four-co-ordinated phosphorus compound (o-Tolylphenylmethylphosphine oxide) by reacting chiral alcohol, chiral amine or chiral thiol, with P-chiral three-co-ordinated phosphorus compound, in presence of electrophile | UNIVERSITY COLLEGE DUBLIN (IE) | 2013-06-25 | — | — | US | claimed |
| WO-2005118603-A1 | CHIRAL PHOSPHORUS COMPOUNDS | UNIVERSITY COLLEGE DUBLIN (IE) | 2005-12-15 | — | — | WO | claimed |
| EP-0272644-B1 | INTERMEDIATES AND THEIR USE IN THE SYNTHESIS OF ORGANIC COMPOUNDS | ZAMBON S.p.A. (IT) | 1993-04-28 | — | — | EP | claimed |
| EP-0217375-B1 | PROCESS FOR PREPARING OPTICALLY ACTIVE CARBONYL COMPOUNDS | ZAMBON S.p.A. (IT) | 1991-01-16 | — | — | EP | claimed |
| US-4973696-A | Stereoselective process for preparing optically active alpha, beta-disubstituted carbonyl compounds | ZAMBON S.P.A. (IT) | 1990-11-27 | — | — | US | claimed |
| EP-0210589-B1 | PROCESS FOR PREPARING OPTICALLY ACTIVE ALPHA-HALOGEN KETALS | ZAMBON S.p.A. (IT) | 1990-09-26 | — | — | EP | claimed |
| US-4764641-A | Process for preparing optically active carbonyl compounds | ZAMBON SPA (IT) | 1988-08-16 | — | — | US | claimed |
| EP-0158913-B1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE ALPHA-ARYLALKANOIC ACIDS AND INTERMEDIATES THEREOF | ZAMBON S.p.A. (IT) | 1988-07-20 | — | — | EP | claimed |
| US-4697036-A | HALOGENATION, REARRANGEMENT | ZAMBON S.P.A. (IT) | 1987-09-29 | — | — | US | claimed |
| EP-0217375-A2 | Process for preparing optically active carbonyl compounds | ZAMBON S.p.A. (IT) | 1987-04-08 | — | — | EP | claimed |
| EP-0158913-A2 | Process for the preparation of optically active alpha-arylalkanoic acids and intermediates thereof | ZAMBON S.p.A. (IT) | 1985-10-23 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10464918-B2 | Process of making somatostatin modulators | SSTR5, SSTR4, SSTR2 | ALDH1A1 4601/4885TSHR 47/4885HIF1A 667/4885 |
| US-20190218202-A1 | PROCESS OF MAKING SOMATOSTATIN MODULATORS | SSTR5, SSTR4, SSTR2 | ALDH1A1 4601/4885TSHR 47/4885HIF1A 667/4885 |
| US-20210087165-A1 | PROCESS OF MAKING SOMATOSTATIN MODULATORS | SSTR5, SSTR4, SSTR2 | ALDH1A1 4601/4885TSHR 47/4885HIF1A 667/4885 |
| US-20200048219-A1 | PROCESS OF MAKING SOMATOSTATIN MODULATORS | SSTR5, SSTR4, SSTR2 | ALDH1A1 4601/4885TSHR 47/4885HIF1A 667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.