Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA7 | P43166 | 3/20 | 0.40 |
| ▸ | CA4 | P22748 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2638043 | 0.86 | MAPK10 (0.45) | DHODHMEN1KMT2ANPC1RAB9A | |
| SCHEMBL2637918 | 0.83 | KMT2A (0.41) | DHODHMEN1KMT2APKMEGFR | |
| SCHEMBL2637350 | 0.83 | ERCC1 (0.48) | DHODHMEN1KMT2APKMKDM4E | |
| SCHEMBL2637592 | 0.82 | MEN1 (0.45) | MEN1KMT2AEGFRSRCNPC1 | |
| SCHEMBL2637908 | 0.81 | NPC1 (0.45) | MEN1KMT2AKDM4ENPC1RAB9A | |
| SCHEMBL2640983 | 0.80 | ALDH1A1 (0.47) | MEN1KMT2AKDM4ENPC1RAB9A | |
| SCHEMBL2637445 | 0.80 | NPC1 (0.38) | DHODHMEN1KMT2APKMKDM4E | |
| SCHEMBL2637500 | 0.79 | ALDH1A1 (0.39) | DHODHMEN1KMT2AKDM4EERCC1 | |
| SCHEMBL2637516 | 0.79 | MEN1 (0.48) | MEN1KMT2AEGFRSRCKDM4E | |
| SCHEMBL2637180 | 0.79 | CGAS (0.46) | MEN1KMT2APKMKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |