Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.42 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.39 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637343 | 0.85 | ALDH1A1 (0.46) | GRM5MEN1KMT2AALDH1A1ERCC1 | |
| SCHEMBL2637556 | 0.80 | POLB (0.46) | KDM4EMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL2637547 | 0.80 | NPC1 (0.48) | GRM5MEN1KMT2ALMNAPKM | |
| SCHEMBL2637908 | 0.80 | NPC1 (0.45) | GRM5HDAC1NOX4NOX1KDM4E | |
| SCHEMBL2637478 | 0.79 | HSP90AA1 (0.47) | GRM5MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL2637595 | 0.75 | MAPT (0.43) | GRM5MEN1KMT2ALMNAPKM | |
| SCHEMBL2637716 | 0.74 | KMT2A (0.47) | KDM4EMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL2638043 | 0.74 | MAPK10 (0.45) | MEN1KMT2AKDRERCC1FEN1 | |
| SCHEMBL2638375 | 0.74 | MAPT (0.48) | GRM5MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL2637610 | 0.73 | MAPK8 (0.48) | KDM4EMEN1KMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |