Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NHERF1 | O14745 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637493 | 0.91 | NHERF1 (0.46) | NPC1RAB9AALDH1A1MAPTLMNA | |
| SCHEMBL2638043 | 0.88 | MAPK10 (0.45) | NPC1RAB9AMEN1KMT2AMAPK10 | |
| SCHEMBL2637592 | 0.86 | MEN1 (0.45) | NPC1RAB9AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL2637207 | 0.82 | CNR2 (0.45) | NPC1RAB9AALDH1A1MAPTLMNA | |
| SCHEMBL2637918 | 0.81 | KMT2A (0.41) | NPC1RAB9AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL2637516 | 0.81 | MEN1 (0.48) | NPC1ALDH1A1MEN1KMT2AEGFR | |
| SCHEMBL2637515 | 0.79 | RAB9A (0.49) | NPC1RAB9AALDH1A1MAPTLMNA | |
| SCHEMBL2637246 | 0.79 | MAPK10 (0.41) | RAB9AMAPTCNR2MEN1KMT2A | |
| SCHEMBL2637180 | 0.79 | CGAS (0.46) | NPC1RAB9AALDH1A1MAPTMEN1 | |
| SCHEMBL2637520 | 0.78 | DHODH (0.45) | NPC1RAB9ANHERF1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |