Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CDC25B | P30305 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | GALK1 | P51570 | 1/20 | 0.34 |
| ▸ | UBE2I | P63279 | 1/20 | 0.34 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.34 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637972 | 0.91 | MEN1 (0.41) | MAT2AMAPTALDH1A1HPGDKDM4E | |
| SCHEMBL2637590 | 0.91 | KDM4E (0.41) | MAT2AMAPTALDH1A1HPGDKDM4E | |
| SCHEMBL2638843 | 0.88 | MAPT (0.35) | MAPTALDH1A1HPGDKDM4EAPAF1 | |
| SCHEMBL2637584 | 0.86 | MET (0.39) | MAT2AMAPTALDH1A1HPGDKDM4E | |
| SCHEMBL2637795 | 0.81 | MEN1 (0.44) | MAPTALDH1A1HPGDKDM4ECDC25B | |
| SCHEMBL2637170 | 0.81 | MAPT (0.43) | MAT2AMAPTALDH1A1HPGDKDM4E | |
| SCHEMBL2637246 | 0.80 | MAPK10 (0.41) | MAPTMEN1KMT2ARAB9ANPSR1 | |
| SCHEMBL2637722 | 0.79 | PSD (0.39) | MAPTALDH1A1HPGDKDM4EAPAF1 | |
| SCHEMBL2637716 | 0.77 | KMT2A (0.47) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL2637406 | 0.76 | MAPT (0.41) | MAPTALDH1A1HPGDKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |