Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | CASP9 | P55211 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637722 | 0.88 | PSD (0.39) | MAPTTHRBTP53HPGDKDM4E | |
| SCHEMBL2638843 | 0.86 | MAPT (0.35) | MAPTTHRBHPGDKDM4EALDH1A1 | |
| SCHEMBL2637724 | 0.84 | TYMP (0.35) | MAPTTHRBTP53HPGDKDM4E | |
| SCHEMBL2637590 | 0.83 | KDM4E (0.41) | MAPTTP53HPGDLMNAKDM4E | |
| SCHEMBL2637972 | 0.81 | MEN1 (0.41) | MAPTHPGDLMNAKDM4EALDH1A1 | |
| SCHEMBL2637594 | 0.81 | MAT2A (0.37) | MAPTTHRBHPGDLMNAKDM4E | |
| SCHEMBL2637584 | 0.79 | MET (0.39) | MAPTTHRBHPGDKDM4EALDH1A1 | |
| SCHEMBL2637795 | 0.77 | MEN1 (0.44) | MAPTTP53HPGDLMNAKDM4E | |
| SCHEMBL2637547 | 0.75 | NPC1 (0.48) | MAPTTP53LMNAMEN1KMT2A | |
| SCHEMBL2637343 | 0.75 | ALDH1A1 (0.46) | MAPTALDH1A1MEN1TDP2CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |