Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637594 | 0.91 | MAT2A (0.37) | KDM4EKMT2AGSK3BMETKDR | |
| SCHEMBL2637722 | 0.88 | PSD (0.39) | KDM4EKMT2APDE10AALDH1A1HPGD | |
| SCHEMBL2637972 | 0.88 | MEN1 (0.41) | KDM4EKMT2AGSK3BALDH1A1HPGD | |
| SCHEMBL2637584 | 0.88 | MET (0.39) | KDM4EKMT2AMETKDRALDH1A1 | |
| SCHEMBL2637170 | 0.83 | MAPT (0.43) | KDM4EKMT2AALDH1A1HPGDGAA | |
| SCHEMBL2637556 | 0.82 | POLB (0.46) | KDM4EKMT2AMETKDRALDH1A1 | |
| SCHEMBL2638843 | 0.79 | MAPT (0.35) | KDM4EKMT2AALDH1A1HPGDGAA | |
| SCHEMBL2637795 | 0.79 | MEN1 (0.44) | KDM4EKMT2AGSK3BALDH1A1HPGD | |
| SCHEMBL2637724 | 0.77 | TYMP (0.35) | KDM4EKMT2AMETKDRALDH1A1 | |
| SCHEMBL2637595 | 0.76 | MAPT (0.43) | KMT2AGAALMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |