Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDF2 | Q9Y5A9 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 2/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637746 | 0.75 | YTHDF2 (0.40) | YTHDF2PIK3CBKDM5AKDM5BKDM4A | |
| SCHEMBL2637787 | 0.73 | PLAT (0.42) | PIK3CBKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL2637509 | 0.68 | HSP90AA1 (0.44) | KDM5AKDM5BKDM4AKDM4CLDHA | |
| SCHEMBL9414195 | 0.61 | YTHDF2 (0.83) | YTHDF2CYP2C9LDHADAOALDH1A1 | |
| SCHEMBL27768491 | 0.59 | YTHDF2 (0.58) | YTHDF2CYP2C9LDHADAOKDM4E | |
| SCHEMBL18778963 | 0.57 | SPR (0.41) | ALDH1A1POLBMAPT | |
| SCHEMBL795977 | 0.57 | DAO (0.46) | YTHDF2KDM5AKDM5BDAOKDM4E | |
| SCHEMBL20075888 | 0.55 | YTHDF2 (0.42) | YTHDF2KDM5AKDM5BKDM4AKDM4C | |
| SCHEMBL9414252 | 0.55 | YTHDF2 (1.00) | YTHDF2KDM4CDAOKDM4EALDH1A1 | |
| SCHEMBL20075886 | 0.55 | NPY5R (0.42) | YTHDF2LDHADAOPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |