SCHEMBL2638409

SCHEMBL2638409

COc1ccccc1NC(=O)Cc1ccc(Cl)c(Oc2cc(C#N)cc(C#N)c2)c1

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.51
KMT2A Q03164 2/20 0.51
ALDH1A1 P00352 1/20 0.51
NPC1 O15118 2/20 0.47
MAPT P10636 1/20 0.47
RAB9A P51151 1/20 0.47
MAPK10 P53779 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
P2RX7 Q99572 2/20 0.47
CRHBP P24387 1/20 0.46
CRHR2 Q13324 1/20 0.46
GAA P10253 2/20 0.46
USP2 O75604 1/20 0.44
TSHR P16473 1/20 0.44
POLB P06746 2/20 0.44
GFER P55789 1/20 0.44
RORC P51449 1/20 0.43
HTT P42858 1/20 0.43
MTNR1B P49286 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4603118 0.92 MAPT (0.54) MEN1KMT2AALDH1A1NPC1MAPT
SCHEMBL2638867 0.90 ALDH1A1 (0.50) MEN1KMT2AALDH1A1NPC1RAB9A
SCHEMBL2639077 0.89 HPGD (0.47) MEN1KMT2AALDH1A1NPC1RAB9A
SCHEMBL2638870 0.88 LMNA (0.44) MEN1KMT2AALDH1A1MAPTSMN1; SMN2
SCHEMBL2638393 0.88 ALDH1A1 (0.46) MEN1KMT2AALDH1A1NPC1MAPT
SCHEMBL2639099 0.87 P2RX7 (0.43) MEN1KMT2AALDH1A1NPC1MAPT
SCHEMBL2639439 0.87 RORC (0.48) ALDH1A1SMN1; SMN2P2RX7GAARORC
SCHEMBL2639075 0.86 POLB (0.48) MEN1KMT2AALDH1A1MAPTSMN1; SMN2
SCHEMBL3832887 0.86 KDM4E (0.52) MEN1KMT2AALDH1A1MAPTSMN1; SMN2
SCHEMBL2638925 0.85 SMN1; SMN2 (0.46) KMT2AALDH1A1MAPTRAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4810529-B2 2011-11-09 JP claimed
EP-1742908-B1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS HOFFMANN LA ROCHE (CH) 2009-11-11 EP claimed
EP-1742908-A1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2007-01-17 EP claimed
WO-2005102989-A1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2005-11-03 WO claimed
EP-1742908-B1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS HOFFMANN LA ROCHE (CH) 2009-11-11 EP disclosed