Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2639075 | 0.93 | POLB (0.48) | KDM4EMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL2638409 | 0.86 | MEN1 (0.51) | MEN1KMT2ASMN1; SMN2MAPTGAA | |
| SCHEMBL2639083 | 0.82 | SMN1; SMN2 (0.48) | KDM4EMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL3837731 | 0.82 | POLB (0.41) | KDM4EMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL2638867 | 0.81 | ALDH1A1 (0.50) | MEN1KMT2ASMN1; SMN2GAAPOLB | |
| SCHEMBL2639077 | 0.81 | HPGD (0.47) | MEN1KMT2ASMN1; SMN2GAATRPM4 | |
| SCHEMBL2640124 | 0.80 | CA12 (0.41) | MEN1KMT2ASMN1; SMN2MAPTPOLB | |
| SCHEMBL2638078 | 0.80 | LMNA (0.51) | KDM4EMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL2638870 | 0.80 | LMNA (0.44) | MEN1KMT2ASMN1; SMN2MAPTGAA | |
| SCHEMBL3835920 | 0.80 | RORC (0.45) | KDM4EMEN1KMT2AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742908-B1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-11 | — | — | EP | claimed |