Sugi Predict

Sugi Predict / Compounds / SCHEMBL2640684

SCHEMBL2640684

SCHEMBL2640684

Sc1nnc(-c2ccnc(Cl)c2)n1-c1ccccc1Cl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADORA2A P29274 2/20 0.39
▸ ADORA1 P30542 1/20 0.39
▸ AKT1 P31749 2/20 0.37
▸ TNKS2 Q9H2K2 4/20 0.36
▸ TNKS O95271 3/20 0.36
▸ RORC P51449 1/20 0.35
▸ RORB Q92753 1/20 0.35
▸ ABL1 P00519 1/20 0.34
▸ PDGFRA P16234 1/20 0.34
▸ CSNK1A1 P48729 1/20 0.34
▸ CDK7 P50613 1/20 0.34
▸ BTK Q06187 1/20 0.34
▸ MAP4K2 Q12851 1/20 0.34
▸ AURKB Q96GD4 1/20 0.34
▸ CLK4 Q9HAZ1 1/20 0.34
▸ DYRK1B Q9Y463 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ MAPK10 P53779 1/20 0.33
▸ SLC2A1 P11166 1/20 0.33
▸ NR3C2 P08235 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2635912 0.87 AKT1 (0.36) AKT1TNKS2TNKSGAASLC2A1
SCHEMBL2640557 0.83 TNKS (0.48) TNKS2TNKSGAAMAPK10KDM4E
SCHEMBL2640727 0.82 HSD11B1 (0.50) AKT1TNKS2TNKSNOTUMHSD11B1
SCHEMBL2640860 0.79 GLA (0.43) AKT1TNKS2TNKSKDM4EHSD11B1
SCHEMBL2640745 0.78 HSP90AA1 (0.40) TNKS2TNKSGAANOTUM
SCHEMBL2640666 0.78 ALDH1A1 (0.35) AKT1TNKS2TNKSHSD11B1
SCHEMBL2640774 0.76 TNKS (0.44) AKT1TNKS2TNKSKDM4EHSD11B1
SCHEMBL14112938 0.75 HSD11B1 (0.51) KDM4EHSD11B1
SCHEMBL2640768 0.73 TNKS2 (0.53) TNKS2TNKSSLC2A1
SCHEMBL2640582 0.73 HPGD (0.56) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8883827-B2 Azole derivatives as WTN pathway inhibitors OSLO UNIVERSITY HOSPITAL HF (NO) 2014-11-11 — — US disclosed
US-8883827-B2 Azole derivatives as WTN pathway inhibitors OSLO UNIVERSITY HOSPITAL HF (NO) 2014-11-11 — — US disclosed
US-8883827-B2 Azole derivatives as WTN pathway inhibitors OSLO UNIVERSITY HOSPITAL HF (NO) 2014-11-11 — — US disclosed
US-20120208828-A1 Azole Derivatives as WTN Pathway Inhibitors OSLO UNIVERSITY HOSPITAL HF (NO) 2012-08-16 — — US disclosed
US-20120208828-A1 Azole Derivatives as WTN Pathway Inhibitors OSLO UNIVERSITY HOSPITAL HF (NO) 2012-08-16 — — US disclosed
US-20120208828-A1 Azole Derivatives as WTN Pathway Inhibitors OSLO UNIVERSITY HOSPITAL HF (NO) 2012-08-16 — — US disclosed
EP-2438052-A1 AZOLE DERIVATIVES AS WTN PATHWAY INHIBITORS Oslo University Hospital HF (NO) 2012-04-11 — — EP disclosed
WO-2010139966-A1 AZOLE DERIVATIVES AS WTN PATHWAY INHIBITORS OSLO UNIVERSITY HOSPITAL HF (NO) 2010-12-09 — — WO disclosed
WO-2010139966-A1 AZOLE DERIVATIVES AS WTN PATHWAY INHIBITORS OSLO UNIVERSITY HOSPITAL HF (NO) 2010-12-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120208828-A1 Azole Derivatives as WTN Pathway Inhibitors WNT1, AXIN2, WNT3 ADORA2A 2856/4885ADORA1 1093/4885AKT1 117/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.