SCHEMBL26420035

SCHEMBL26420035

Cc1cc(=O)n(-c2ccc(Cl)cc2F)c(=O)n1N

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
S1PR4 O95977 1/20 0.39
S1PR1 P21453 1/20 0.39
S1PR5 Q9H228 1/20 0.39
AOC3 Q16853 4/20 0.38
MYC P01106 2/20 0.36
NR4A1 P22736 1/20 0.36
SLC22A12 Q96S37 1/20 0.35
POLB P06746 1/20 0.34
CCR2 P41597 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
GLA P06280 1/20 0.33
NOTUM Q6P988 1/20 0.33
CCR1 P32246 1/20 0.33
CCR5 P51681 1/20 0.33
MAPK11 Q15759 1/20 0.33
MAPK14 Q16539 1/20 0.33
HTR2B P41595 1/20 0.33
PDE4B Q07343 1/20 0.32
PDE4D Q08499 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10575241 0.84 S1PR4 (0.42) S1PR4S1PR1S1PR5AOC3MYC
SCHEMBL9522971 0.81 SLC22A12 (0.34) S1PR4S1PR1S1PR5AOC3SLC22A12
SCHEMBL26420033 0.76 S1PR4 (0.39) S1PR4S1PR1S1PR5AOC3MYC
SCHEMBL20575403 0.74 MYC (0.54) S1PR4S1PR1S1PR5AOC3MYC
SCHEMBL10574822 0.72 SMN1; SMN2 (0.61) S1PR4S1PR1S1PR5AOC3SLC22A12
SCHEMBL7562176 0.72 HSD11B1 (0.36) S1PR4S1PR1S1PR5AOC3SLC22A12
SCHEMBL29709206 0.72 HSD11B1 (0.36) S1PR4S1PR1S1PR5AOC3SLC22A12
SCHEMBL31442447 0.69 ALDH1A1 (0.51) CCR2SMN1; SMN2CCR1CCR5PDE4B
SCHEMBL10911510 0.69 ALDH1A1 (0.51) CCR2SMN1; SMN2CCR1CCR5PDE4B
SCHEMBL27531900 0.69 TAS2R14 (0.36) S1PR4S1PR1S1PR5SLC22A12CCR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230131260-A1 SUBSTITUTED THIOPHENYL URACILS, SALTS THEREOF AND THE USE THEREOF AS HERBICIDAL AGENTS SYNGENTA CROP PROTECTION AG (CH) 2023-04-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230131260-A1 SUBSTITUTED THIOPHENYL URACILS, SALTS THEREOF AND THE USE THEREOF AS HERBICIDAL AGENTS UNG, TYMP, TYMS S1PR4 4304/4885S1PR1 4065/4885S1PR5 4205/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.