Sugi Predict

Sugi Predict / Compounds / SCHEMBL2642375

SCHEMBL2642375

SCHEMBL2642375

FC(F)(F)c1cc(S)ccn1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LOXL2 Q9Y4K0 2/20 0.52
▸ TRPV4 Q9HBA0 1/20 0.50
▸ LOX P28300 1/20 0.50
▸ NOTUM Q6P988 1/20 0.43
▸ IDO1 P14902 1/20 0.43
▸ SMARCA2 P51531 1/20 0.40
▸ SMARCA4 P51532 1/20 0.40
▸ AR P10275 1/20 0.39
▸ CA2 P00918 1/20 0.39
▸ CHKA P35790 1/20 0.39
▸ NOS3 P29474 1/20 0.38
▸ NOS2 P35228 1/20 0.38
▸ KCNQ2 O43526 1/20 0.37
▸ MAP4K4 O95819 1/20 0.36
▸ HDAC4 P56524 1/20 0.36
▸ SYK P43405 2/20 0.35
▸ LRRK2 Q5S007 1/20 0.35
▸ PARP15 Q460N3 1/20 0.34
▸ PARP14 Q460N5 1/20 0.34
▸ PARP10 Q53GL7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30568085 1.00 LOXL2 (0.52) LOXL2TRPV4LOXNOTUMIDO1
SCHEMBL22440549 0.98 LOXL2 (0.50) LOXL2TRPV4LOXNOTUMIDO1
SCHEMBL18972271 0.77 LMNA (0.40) LOXL2TRPV4SYK
SCHEMBL1643559 0.74 LOXL2 (0.53) LOXL2TRPV4LOXNOTUMIDO1
SCHEMBL2327508 0.74 NOS3 (0.59) LOXL2LOXNOTUMIDO1SMARCA2
SCHEMBL30328281 0.74 LOXL2 (0.53) LOXL2TRPV4LOXNOTUMIDO1
SCHEMBL2642373 0.74 LOXL2 (0.53) LOXL2TRPV4LOXNOTUMIDO1
SCHEMBL1199840 0.73 LOXL2 (0.52) LOXL2TRPV4LOXNOTUMIDO1
SCHEMBL365253 0.73 LOXL2 (0.52) LOXL2TRPV4LOXNOTUMIDO1
SCHEMBL2261695 0.73 LOXL2 (0.52) LOXL2TRPV4LOXNOTUMIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250066357-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2025-02-27 — — US disclosed
US-12187721-B2 Protein tyrosine phosphatase inhibitors ARRAY BIOPHARMA INC. (US) 2025-01-07 — — US disclosed
CN-114341124-B Protein tyrosine phosphatase inhibitors ARRAY生物制药公司 2024-09-20 — — CN disclosed
US-11883387-B2 PqsR inverse agonists Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2024-01-30 — — US disclosed
US-11685748-B2 Spiro aromatic ring compound and application thereof ETERN BIOPHARMA (SHANGHAI) CO., LTD. (CN) 2023-06-27 — — US disclosed
EP-3867238-B1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS ARRAY BIOPHARMA INC (US) 2023-06-07 — — EP disclosed
EP-3867238-B1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS ARRAY BIOPHARMA INC (US) 2023-06-07 — — EP disclosed
US-11420976-B2 Heterocyclic compounds as anti-viral agents ENANTA PHARMACEUTICALS, INC. (US) 2022-08-23 — — US disclosed
CN-114341124-A Protein tyrosine phosphatase inhibitors ARRAY生物制药公司 2022-04-12 — — CN disclosed
US-20210380582-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2021-12-09 — — US disclosed
US-10428075-B2 Coelenterazine analogues PROMEGA CORPORATION (US) 2019-10-01 — — US disclosed
WO-2018020474-A1 SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS LUPIN LIMITED (IN) 2018-02-01 — — WO disclosed
EP-2938344-B1 PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES MERCK SHARP & DOHME (US) 2017-06-21 — — EP disclosed
US-8765789-B2 2-pyridinecarboxamide derivatives MSD K.K. (JP) 2014-07-01 — — US disclosed
US-20130085156-A1 NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES MSD K.K. (JP) 2013-04-04 — — US disclosed
US-8344003-B2 2-pyridinecarboxamide derivatives MSD K. K. (JP) 2013-01-01 — — US disclosed
US-20100041660-A1 NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES MSD K.K. (JP) 2010-02-18 — — US disclosed
US-7629362-B2 2-pyridine carboxamide derivatives BANYU PHARMACEUTICAL CO., LTD. (JP) 2009-12-08 — — US disclosed
US-20060258701-A1 Novel 2-pyridinecarboxamide derivatives BANYU PHARMACEUTICAL CO., LTD. (JP) 2006-11-16 — — US disclosed
EP-1598349-A1 NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES BANYU PHARMACEUTICAL CO., LTD. (JP) 2005-11-23 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250066357-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS PPM1A, PPM1F, PPP5C LOXL2 1202/4885TRPV4 4018/4885LOX 484/4885
US-12187721-B2 Protein tyrosine phosphatase inhibitors PPM1A, PTP4A1, PPP5C LOXL2 1268/4885TRPV4 4080/4885LOX 504/4885
US-20210380582-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS PPM1A, PTP4A1, PPP5C LOXL2 1268/4885TRPV4 4080/4885LOX 504/4885
US-10428075-B2 Coelenterazine analogues GLB1, SI, TCF7L2 LOXL2 1006/4885TRPV4 3283/4885LOX 1977/4885
US-20130085156-A1 NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES GCKR, GCK, HK2 LOXL2 2232/4885TRPV4 2071/4885LOX 1831/4885
US-11883387-B2 PqsR inverse agonists QRFPR, P2RY11, QARS1 LOXL2 4197/4885TRPV4 840/4885LOX 4457/4885
US-11420976-B2 Heterocyclic compounds as anti-viral agents VIP, ACE, FURIN LOXL2 4229/4885TRPV4 1510/4885LOX 2759/4885
US-11685748-B2 Spiro aromatic ring compound and application thereof PTPN1, PTPN11, PTPN5 LOXL2 2650/4885TRPV4 503/4885LOX 1757/4885
US-20060258701-A1 Novel 2-pyridinecarboxamide derivatives GCKR, GCK, HK2 LOXL2 2252/4885TRPV4 2132/4885LOX 1812/4885
US-20100041660-A1 NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES GCKR, GCK, HK2 LOXL2 2232/4885TRPV4 2071/4885LOX 1831/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.