Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.35 |
| ▸ | REN | P00797 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11254010 | 0.89 | CYP1A2 (0.48) | ALDH1A1KMT2ACYP1A2METAP2CTSL | |
| SCHEMBL19987609 | 0.87 | CYP1A2 (0.38) | ALDH1A1KMT2ACYP1A2METAP2SIGMAR1 | |
| SCHEMBL2458694 | 0.87 | ALDH1A1 (0.46) | ALDH1A1KMT2ACYP1A2METAP2CTSL | |
| SCHEMBL31509052 | 0.85 | CYP1A2 (0.48) | ALDH1A1KMT2ACYP1A2METAP2CTSL | |
| SCHEMBL18727735 | 0.81 | SIGMAR1 (0.46) | ALDH1A1KMT2ASIGMAR1CPB2CYP3A4 | |
| SCHEMBL11003236 | 0.81 | LMNA (0.53) | ALDH1A1KMT2ACYP1A2METAP2REN | |
| SCHEMBL9713236 | 0.80 | CYP1A2 (0.50) | ALDH1A1KMT2ACYP1A2METAP2REN | |
| SCHEMBL25111365 | 0.80 | NOS1 (0.40) | ALDH1A1KMT2ACYP1A2SIGMAR1CPB2 | |
| SCHEMBL11000110 | 0.79 | LMNA (0.57) | ALDH1A1KMT2ACYP1A2METAP2CTSL | |
| SCHEMBL9213750 | 0.79 | ALDH1A1 (0.44) | ALDH1A1KMT2ACYP1A2METAP2REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023069348-A1 | SMALL MOLECULES FOR DOT1L DEGRADATION AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-04-27 | — | — | WO | disclosed |