Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.39 |
| ▸ | RXRB | P28702 | 4/20 | 0.39 |
| ▸ | CYP26B1 | Q9NR63 | 4/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | RARB | P10826 | 9/20 | 0.34 |
| ▸ | RARG | P13631 | 8/20 | 0.34 |
| ▸ | RXRG | P48443 | 3/20 | 0.34 |
| ▸ | RARA | P10276 | 6/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8736104 | 0.71 | RXRA (0.50) | RXRARXRBCYP26B1CYP26A1CYP3A4 | |
| SCHEMBL6148854 | 0.67 | RXRA (0.46) | RXRARXRBCYP26B1CYP26A1CYP3A4 | |
| SCHEMBL6148846 | 0.67 | RXRA (0.46) | RXRARXRBCYP26B1CYP26A1CYP3A4 | |
| SCHEMBL6147928 | 0.66 | RXRA (0.44) | RXRARXRBCYP26B1CYP26A1CYP3A4 | |
| SCHEMBL6147935 | 0.66 | RXRA (0.44) | RXRARXRBCYP26B1CYP26A1CYP3A4 | |
| SCHEMBL1618997 | 0.65 | RXRA (0.40) | RXRARXRBCYP26B1CYP26A1CYP3A4 | |
| SCHEMBL7460363 | 0.65 | ALDH1A1 (0.36) | RXRARXRBRXRGPPARG | |
| SCHEMBL7759792 | 0.64 | RXRA (0.70) | RXRARXRBCYP26B1CYP26A1CYP3A4 | |
| SCHEMBL7464569 | 0.64 | CCR3 (0.35) | RXRA | |
| SCHEMBL6147966 | 0.62 | PPARG (0.53) | RXRARXRBCYP26B1CYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070099937-A1 | Substituted Pyrrolones As Allosteric Modulators of Glucokinase | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099937-A1 | Substituted Pyrrolones As Allosteric Modulators of Glucokinase | GCK, GCKR, PDXK | RXRA 3816/4885RXRB 3221/4885CYP26B1 1404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.